PMID- 1703203
OWN - NLM
STAT- MEDLINE
DCOM- 19910225
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 173
IP  - 2
DP  - 1991 Feb 1
TI  - Anti-interferon gamma treatment blocks the ability of glutaraldehyde-polymerized 
      allergens to inhibit specific IgE responses.
PG  - 279-85
AB  - The lymphokines interleukin 4 and interferon gamma (IFN-gamma) have been shown to 
      play an important role in regulation of polyclonal immunoglobulin E (IgE) and 
      IgG2a responses in vitro and in vivo. We demonstrate here that treatment with 
      chemically modified ovalbumin (OA) results in long-lived, 97-99% inhibition of 
      allergen-specific murine IgE responses and 10(3)-10(4)-fold increases in anti-OA 
      IgG2a. Responses to unrelated antigens are not affected. Treatment with 
      unmodified OA under the same conditions fails to inhibit primary or secondary IgE 
      responses or to increase IgG2a but does lead to pronounced increases in 
      OA-specific IgG1 production. Glutaraldehyde-polymerized ovalbumin 
      (OA-POL)-induced changes in IgE and IgG2a responses are abrogated by in vivo 
      treatment with purified monoclonal anti-IFN-gamma antibody (XMG 1.2), a finding 
      indicative of preferential IFN-gamma production upon exposure to chemically 
      modified, but not native, allergen. The results suggest the possibility that the 
      pattern of cytokine synthesis elicited after exposure to protein antigens, and 
      the resulting immune response, may be dependent upon the form of antigen to which 
      the individual is exposed and consequently may be subject to manipulation.
FAU - HayGlass, K T
AU  - HayGlass KT
AD  - Department of Immunology, University of Manitoba, Winnipeg, Canada.
FAU - Stefura, B P
AU  - Stefura BP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Allergens)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Epitopes)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Polymers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
RN  - T3C89M417N (Glutaral)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Epitopes/immunology
MH  - Female
MH  - Glutaral/*immunology
MH  - Immunization
MH  - Immunoglobulin E/antagonists & inhibitors/*biosynthesis
MH  - Immunoglobulin G/antagonists & inhibitors/biosynthesis
MH  - Interferon-gamma/biosynthesis/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Ovalbumin/*immunology
MH  - Polymers
MH  - Rats
PMC - PMC2118787
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
PMCR- 1991/08/01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
PHST- 1991/08/01 00:00 [pmc-release]
AID - 91108324 [pii]
AID - 10.1084/jem.173.2.279 [doi]
PST - ppublish
SO  - J Exp Med. 1991 Feb 1;173(2):279-85. doi: 10.1084/jem.173.2.279.