PMID- 17032199
OWN - NLM
STAT- MEDLINE
DCOM- 20061219
LR  - 20220419
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 101
IP  - 10
DP  - 2006 Oct
TI  - Rotavirus infection frequency and risk of celiac disease autoimmunity in early 
      childhood: a longitudinal study.
PG  - 2333-40
AB  - OBJECTIVE: Few studies have assessed the role of specific gastrointestinal 
      infections in celiac disease. We investigated whether increased frequency of 
      rotavirus infection, a common cause of gastrointestinal infection and 
      inflammation, predicts increased risk of celiac disease autoimmunity. METHODS: A 
      cohort of 1,931 children from the Denver metropolitan area who carried celiac 
      disease human leukocyte antigen (HLA) risk alleles were followed from infancy for 
      development of celiac disease autoimmunity, defined as positivity at two or more 
      subsequent clinic visits for tissue transglutaminase (tTG) autoantibodies 
      measured using a radioimmunoassay with human recombinant tTG. Blood samples were 
      obtained at ages 9, 15, and 24 months, and annually thereafter. Rotavirus 
      antibodies were assayed using an indirect enzyme immunoassay in serial serum 
      samples from each case and two matched controls. Frequency of infections were 
      estimated by the number of increases (> 2 assay coefficient of variation) in 
      rotavirus antibody between clinic visits. RESULTS: Fifty-four cases developed 
      celiac disease autoimmunity at a median age of 4.4 yr. Thirty-six had an 
      intestinal biopsy, of which 27 (75%) were positive for celiac disease. Frequent 
      rotavirus infections predicted a higher risk of celiac disease autoimmunity 
      (compared with zero infections, rate ratio 1.94, 95% confidence interval [CI] 
      0.39-9.56, for one infection and rate ratio 3.76, 95% CI 0.76-18.7, for > or = 2 
      infections, rate ratio for trend per increase in number of infections = 1.94, 95% 
      CI 1.04-3.61, p = 0.037). The result was similar after adjustment for gender, 
      ethnic group, maternal education, breast-feeding, day-care attendance, number of 
      siblings, season of birth, and number of HLA DR3-DQ2 haplotypes. CONCLUSIONS: 
      This prospective study provides the first indication that a high frequency of 
      rotavirus infections may increase the risk of celiac disease autoimmunity in 
      childhood in genetically predisposed individuals.
FAU - Stene, Lars C
AU  - Stene LC
AD  - Barbara Davis Center for Childhood Diabetes, University of Colorado School of 
      Medicine, Aurora, Colorado 80045-6511, USA.
FAU - Honeyman, Margo C
AU  - Honeyman MC
FAU - Hoffenberg, Edward J
AU  - Hoffenberg EJ
FAU - Haas, Joel E
AU  - Haas JE
FAU - Sokol, Ronald J
AU  - Sokol RJ
FAU - Emery, Lisa
AU  - Emery L
FAU - Taki, Iman
AU  - Taki I
FAU - Norris, Jill M
AU  - Norris JM
FAU - Erlich, Henry A
AU  - Erlich HA
FAU - Eisenbarth, George S
AU  - Eisenbarth GS
FAU - Rewers, Marian
AU  - Rewers M
LA  - eng
GR  - AI 50864/AI/NIAID NIH HHS/United States
GR  - DK 32083/DK/NIDDK NIH HHS/United States
GR  - DK 32493/DK/NIDDK NIH HHS/United States
GR  - DK 50979/DK/NIDDK NIH HHS/United States
GR  - M01 RR00069/RR/NCRR NIH HHS/United States
GR  - P30 DK 57516/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (Antibodies, Viral)
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - EC 2.3.2.13 (Transglutaminases)
SB  - IM
CIN - Am J Gastroenterol. 2007 Aug;102(8):1831. PMID: 17686081
MH  - Antibodies, Viral/*blood
MH  - Autoantibodies/blood
MH  - Autoimmunity/*physiology
MH  - Case-Control Studies
MH  - Celiac Disease/*blood/*etiology/pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Infant
MH  - Longitudinal Studies
MH  - Male
MH  - Rotavirus/*immunology
MH  - Rotavirus Infections/blood/complications/*epidemiology
MH  - Transglutaminases/immunology
EDAT- 2006/10/13 09:00
MHDA- 2006/12/21 09:00
CRDT- 2006/10/13 09:00
PHST- 2006/10/13 09:00 [pubmed]
PHST- 2006/12/21 09:00 [medline]
PHST- 2006/10/13 09:00 [entrez]
AID - AJG741 [pii]
AID - 10.1111/j.1572-0241.2006.00741.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2006 Oct;101(10):2333-40. doi: 
      10.1111/j.1572-0241.2006.00741.x.