PMID- 17033284
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070622
LR  - 20191110
IS  - 0267-1379 (Print)
IS  - 0267-1379 (Linking)
VI  - 18
IP  - 2
DP  - 2002 Mar
TI  - Recent developments in celiac disease.
PG  - 182-6
AB  - Celiac disease is a common disorder associated with a substantially increased 
      standardized mortality ratio if it is left untreated or if the diagnosis is 
      delayed. Diagnostic sensitivity of serologic testing is improved by the addition 
      of IgG-based testing to standard IgA-based serologic testing for endomysial or 
      transglutaminase autoantibodies. The role of intestinal permeability testing as 
      an additional tool for screening and for monitoring the response to a gluten-free 
      diet is discussed. The importance of diagnosing celiac disease in two clinical 
      situations is considered: first, before immune-stimulating therapy with 
      interferon for viral hepatitis is begun and second, in pregnancy when not only 
      maternal but also paternal celiac disease may affect fetal outcome. The strong 
      genetic component of the etiology of celiac disease is illustrated by a 
      monozygotic twin concordance of nearly 90%, with susceptibility conveyed by human 
      leukocyte antigen (HLA) genotypes DQ2 or DQ8 and one or more non-HLA genes. 
      Progress toward identifying these genes from large linkage and association 
      studies is reviewed.
FAU - Moodie, Simon
AU  - Moodie S
AD  - Department of Gastroenterology (GKT), The Rayne Institute, St. Thomas' Hospital, 
      London, United Kingdom.
FAU - Ciclitira, Paul
AU  - Ciclitira P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Opin Gastroenterol
JT  - Current opinion in gastroenterology
JID - 8506887
EDAT- 2006/10/13 09:00
MHDA- 2006/10/13 09:01
CRDT- 2006/10/13 09:00
PHST- 2006/10/13 09:00 [pubmed]
PHST- 2006/10/13 09:01 [medline]
PHST- 2006/10/13 09:00 [entrez]
AID - 00001574-200203000-00005 [pii]
AID - 10.1097/00001574-200203000-00005 [doi]
PST - ppublish
SO  - Curr Opin Gastroenterol. 2002 Mar;18(2):182-6. doi: 
      10.1097/00001574-200203000-00005.