PMID- 1703387
OWN - NLM
STAT- MEDLINE
DCOM- 19910228
LR  - 20190812
IS  - 0001-6322 (Print)
IS  - 0001-6322 (Linking)
VI  - 80
IP  - 6
DP  - 1990
TI  - Evolution of post-natal herpes simplex virus encephalitis to multicystic 
      encephalopathy.
PG  - 666-70
AB  - A 3-week-old, previously healthy infant developed biopsy-proven Herpes virus type 
      2 (HSV-2) encephalitis. The encephalitis was characterized by cells having 
      intranuclear inclusions and was without evidence of inflammation or hemorrhage. 
      Neuroimaging studies did not show any destructive lesions in the brain. In spite 
      of antiviral therapy, the infant's neurological conditions deteriorated, and the 
      patient died at the age of 18 weeks. Post-mortem examination showed that most of 
      the cerebral hemispheres were replaced by multiloculated cystic cavities of 
      various sizes, typical of multicystic encephalopathy (MCE). The cystic lesions 
      were randomly distributed and were not confined to any vascular territory. By 
      light microscopy, there were no features of viral infection in the brain. 
      Although in situ hybridization of the biopsy specimen taken during the acute 
      phase of the disease demonstrated abundant HSV genome, this same method failed to 
      detect HSV on the post-mortem specimen. These findings suggest that HSV-2 can 
      induce MCE. Furthermore, the absence of histological features of viral 
      encephalitis and the failure to demonstrate viral genome in the brain at autopsy 
      does not exclude an infectious etiology in certain cases of MCE.
FAU - Chang, Y
AU  - Chang Y
AD  - Department of Pathology, Stanford University School of Medicine, CA 94305-5324.
FAU - Soffer, D
AU  - Soffer D
FAU - Horoupian, D S
AU  - Horoupian DS
FAU - Weiss, L M
AU  - Weiss LM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Acta Neuropathol
JT  - Acta neuropathologica
JID - 0412041
SB  - IM
MH  - Autopsy
MH  - Biopsy
MH  - Electroencephalography
MH  - Encephalitis/diagnosis/microbiology/*pathology
MH  - Herpes Simplex/diagnosis/microbiology/*pathology
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Staining and Labeling
MH  - Temporal Lobe/pathology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1007/BF00307637 [doi]
PST - ppublish
SO  - Acta Neuropathol. 1990;80(6):666-70. doi: 10.1007/BF00307637.