PMID- 17034986
OWN - NLM
STAT- MEDLINE
DCOM- 20070223
LR  - 20061218
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 25
IP  - 11-12
DP  - 2006 Nov-Dec
TI  - [Heparin-induced thrombocytopenia: report of four cases in severely burned 
      patients].
PG  - 1135-9
AB  - Heparin-induced thrombocytopenia (HIT) is a dangerous complication of heparin 
      therapy caused by an antibody against heparin/Platelet Factor 4 (PF4) complex. 
      HIT complicates about 2% of treatment with unfractionated heparin (UFH). The aim 
      of the study was to determine the incidence of HIT in a burn center and to report 
      four cases in severely burned patients. HIT was documented in 2.8% of burns 
      treated with UFH administered for antithrombotic prophylaxis and in none of burns 
      receiving low molecular weight heparin (LMWH). All HIT cases occurred after 
      extensive deep burns (mean total body surface area or TBSA was 60+/-21%) and 
      three cases had above 75% of burn. We suggest that systemic platelet activation 
      after thermal injury and local production of PF4 in the burn wound could 
      participate to development of HIT. The risk is a late diagnosis since thrombosis 
      clinical detection under burned skin is difficult. HIT appears during the first 
      week of UHF treatment at the same time as a unstable period of fluctuating 
      platelets.
FAU - Bargues, L
AU  - Bargues L
AD  - Centre de traitement des brules, hopital d'instruction des Armees-Percy, 101, 
      avenue Henri-Barbusse, 92141 Clamart, France. bargol@aol.com <bargol@aol.com>
FAU - Foissaud, V
AU  - Foissaud V
FAU - Jault, P
AU  - Jault P
FAU - Samson, T
AU  - Samson T
FAU - Carsin, H
AU  - Carsin H
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Thrombopenie induite par l'heparine de type II: description de quatre 
      observations chez le brule grave.
DEP - 20061010
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Burns/classification/*therapy
MH  - Heparin/*adverse effects
MH  - Heparin, Low-Molecular-Weight/adverse effects
MH  - Humans
MH  - Male
MH  - Platelet Activation
MH  - Thrombocytopenia/*chemically induced/epidemiology
EDAT- 2006/10/13 09:00
MHDA- 2007/02/24 09:00
CRDT- 2006/10/13 09:00
PHST- 2005/05/20 00:00 [received]
PHST- 2006/03/28 00:00 [accepted]
PHST- 2006/10/13 09:00 [pubmed]
PHST- 2007/02/24 09:00 [medline]
PHST- 2006/10/13 09:00 [entrez]
AID - S0750-7658(06)00206-1 [pii]
AID - 10.1016/j.annfar.2006.03.037 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2006 Nov-Dec;25(11-12):1135-9. doi: 
      10.1016/j.annfar.2006.03.037. Epub 2006 Oct 10.