PMID- 17036259
OWN - NLM
STAT- MEDLINE
DCOM- 20071017
LR  - 20181113
IS  - 0940-1334 (Print)
IS  - 0940-1334 (Linking)
VI  - 257
IP  - 1
DP  - 2007 Feb
TI  - Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not 
      associated with response to electroconvulsive therapy in major depressive 
      disorder.
PG  - 31-5
AB  - The aim of the present study was to examine an association of brain-derived 
      neurotrophic factor (BDNF) polymorphisms G196A and C270T and the response to 
      electroconvulsive therapy (ECT) in major depressive disorder (MDD). The study 
      group consisted of 119 patients consecutively admitted for ECT in the Department 
      of Psychiatry, Tampere University Hospital. All patients fulfilled the diagnostic 
      criteria of DSM-IV for MDD. ECT was administered three times a week with a brief 
      pulse constant current device. The Montgomery and Asberg Depression Rating Scale 
      (MADRS) was used as an outcome measure of depression. Genotyping was performed 
      using fluorescent allele-specific TaqMan probes. No association between either 
      G196A or C270T and the response to ECT was found in the whole population. There 
      were no significant differences in responses between men and women or between 
      psychotic and non-psychotic patients. However, within subgroups such as in 
      psychotic and in late-onset depression CC genotype of C270T may predict good 
      response. BDNF may not be associated with response to ECT in general, but some 
      association in subgroups may exist.
FAU - Huuhka, Kaija
AU  - Huuhka K
AD  - Medical School, University of Tampere, 33014 Tampere, Finland.
FAU - Anttila, Sami
AU  - Anttila S
FAU - Huuhka, Martti
AU  - Huuhka M
FAU - Leinonen, Esa
AU  - Leinonen E
FAU - Rontu, Riikka
AU  - Rontu R
FAU - Mattila, Kari
AU  - Mattila K
FAU - Lehtimaki, Terho
AU  - Lehtimaki T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age of Onset
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depressive Disorder, Major/*genetics/psychology/*therapy
MH  - *Electroconvulsive Therapy
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sex Characteristics
MH  - Treatment Outcome
EDAT- 2006/10/13 09:00
MHDA- 2007/10/18 09:00
CRDT- 2006/10/13 09:00
PHST- 2005/09/12 00:00 [received]
PHST- 2006/06/27 00:00 [accepted]
PHST- 2006/10/13 09:00 [pubmed]
PHST- 2007/10/18 09:00 [medline]
PHST- 2006/10/13 09:00 [entrez]
AID - 10.1007/s00406-006-0679-x [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2007 Feb;257(1):31-5. doi: 
      10.1007/s00406-006-0679-x.