PMID- 17036385
OWN - NLM
STAT- MEDLINE
DCOM- 20061205
LR  - 20190430
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 12
IP  - 38
DP  - 2006 Oct 14
TI  - An herbal formula, CGX, exerts hepatotherapeutic effects on 
      dimethylnitrosamine-induced chronic liver injury model in rats.
PG  - 6142-8
AB  - AIM: To evaluate the therapeutic effect of Chunggan extract (CGX), a modified 
      traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine 
      (DMN)-induced chronic liver injury model in rats. METHODS: Liver injuries were 
      induced in Wistar rats by injection of DMN (ip, 10 mg/mL per kg) for 3 
      consecutive days per week for 4 wk. The rats were administered with CGX (po, 100 
      or 200 mg/kg per day) or distilled water as a control daily for 4 wk starting 
      from the 15(th) d of the DMN treatment. Biochemical parameters (serum albumin, 
      bilirubin, ALP, AST and ALT), lipid peroxides, hydroxyproline, as well as 
      histological changes in liver tissues were analyzed. In addition, gene expression 
      of TNF-alpha, TGF-beta, TIMP-1, TIMP-2, PDGF-beta, and MMP-2, all of which are 
      known to be associated with liver fibrosis, were analyzed using real-time PCR. 
      RESULTS: CGX administration restored the spleen weight to normal after having 
      been increased by DMN treatment. Biochemical analysis of the serum demonstrated 
      that CGX significantly decreased the serum level of ALP (P < 0.05), ALT (P < 
      0.01), and AST (P < 0.01) that had been elevated by DMN treatment. CGX 
      administration moderately lowered lipid peroxide production and markedly lowered 
      hydroxyproline generation caused by DMN treatment in accordance with 
      histopathological examination. DMN treatment induced a highly up-regulated 
      expression of TNF-alpha, TGF-beta, TIMP-1, TIMP-2, PDGF-beta, and MMP-2. Of 
      these, the gene expression encoding PDGF-beta and MMP-2 was still further 
      enhanced 2 wk after secession of the 4-wk DMN treatment, and was remarkably 
      ameliorated by CGX administration. CONCLUSION: CGX exhibits hepatotherapeutic 
      proper-ties against chronic hepatocellular destruction and consequential liver 
      fibrosis.
FAU - Shin, Jang-Woo
AU  - Shin JW
AD  - East-West Cancer Center, Dunsan Oriental Hospital of Oriental medical College of 
      Daejeon University, 1136 Dunsan-dong, Seo-gu, Daejeon 302-122, South Korea.
FAU - Son, Jin-Young
AU  - Son JY
FAU - Oh, Se-Mi
AU  - Oh SM
FAU - Han, Seung-Hyun
AU  - Han SH
FAU - Wang, Jing-Hua
AU  - Wang JH
FAU - Cho, Jung-Hyo
AU  - Cho JH
FAU - Cho, Chong-Kwan
AU  - Cho CK
FAU - Yoo, Hwa-Seung
AU  - Yoo HS
FAU - Lee, Yeon-Weol
AU  - Lee YW
FAU - Lee, Myong-Min
AU  - Lee MM
FAU - Hu, Xiao-Ping
AU  - Hu XP
FAU - Son, Chang-Gue
AU  - Son CG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (chunggan)
RN  - M43H21IO8R (Dimethylnitrosamine)
RN  - RMB44WO89X (Hydroxyproline)
SB  - IM
MH  - Animals
MH  - Dimethylnitrosamine
MH  - Drugs, Chinese Herbal/*pharmacology/therapeutic use
MH  - Gene Expression
MH  - Hydroxyproline/drug effects
MH  - Lipid Peroxidation/drug effects
MH  - Liver/*drug effects/pathology
MH  - Liver Cirrhosis/*prevention & control
MH  - Liver Diseases/blood/drug therapy/pathology
MH  - Male
MH  - Organ Size
MH  - Rats
MH  - Rats, Wistar
MH  - Spleen/pathology
PMC - PMC4088107
EDAT- 2006/10/13 09:00
MHDA- 2006/12/09 09:00
PMCR- 2006/10/14
CRDT- 2006/10/13 09:00
PHST- 2006/10/13 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/10/13 09:00 [entrez]
PHST- 2006/10/14 00:00 [pmc-release]
AID - 10.3748/wjg.v12.i38.6142 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2006 Oct 14;12(38):6142-8. doi: 10.3748/wjg.v12.i38.6142.