PMID- 17039418
OWN - NLM
STAT- MEDLINE
DCOM- 20070130
LR  - 20220409
IS  - 1641-4640 (Print)
IS  - 1509-572X (Linking)
VI  - 44
IP  - 3
DP  - 2006
TI  - The role of trkB receptor in the formation of post-traumatic neuroma.
PG  - 221-7
AB  - The outcome of peripheral nerve injury is often impaired by post-traumatic 
      neuroma developing at the injury site. Neuroma is usually accompanied by 
      neuropathic pain, which is usually resistant to most analgesics and presents a 
      serious clinical problem. The mechanisms underlying post-traumatic neuroma remain 
      unclear, but they are likely associated with regeneration processes. 
      Brain-derived neurotrophic factor (BDNF) and its receptor, trkB, are strongly 
      implicated in axonal regeneration after injury. The aim of this work was to 
      examine the role of trkB in post-traumatic neuroma formation. The sciatic nerve 
      was transected in wild-type and heterozygous trkB-deficient mice. The nerve was 
      either left cut or immediately sewn up or the gap injury model was performed. The 
      gap was provided with an autologous or cross (obtained from another genetic 
      group) graft. Sixteen weeks after surgery, the animals were sacrificed and 
      histologic evaluations were performed. We found very limited or no neuroma 
      formation in wild-type animals, regardless of the surgical procedure. In the 
      majority of trkB-deficient mice, the post-traumatic neuroma was found at the end 
      of the proximal stump of the transected nerve. In the gap injury model, in 
      trkB-deficient animals receiving wild-type graft, there was no neuroma at the 
      join site between the graft and distal stump of the nerve. In contrast, if the 
      graft was autologous, neuroma formed at both joints. We also noticed many more 
      mast cells accumulated at the surgery site in trkB-deficient than in wild-type 
      animals. These results indicate the important role of BDNF receptor in 
      post-traumatic neuroma formation.
FAU - Kotulska, Katarzyna
AU  - Kotulska K
AD  - Department of Neurology, The Children's Memorial Health Institute, Al Dzieci 
      Polskich 20, 04-730 Warsaw, Poland. k.kotulska@czd.pl
FAU - Larysz-Brysz, Magdalena
AU  - Larysz-Brysz M
FAU - Marcol, Wieslaw
AU  - Marcol W
FAU - Grajkowska, Wieslawa
AU  - Grajkowska W
FAU - Jozwiak, Sergiusz
AU  - Jozwiak S
FAU - Lewin-Kowalik, Joanna
AU  - Lewin-Kowalik J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Folia Neuropathol
JT  - Folia neuropathologica
JID - 9437431
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Axotomy
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Neoplasms, Post-Traumatic/*metabolism
MH  - Nerve Regeneration/*physiology
MH  - Neuroma/*metabolism
MH  - Receptor, trkB/*metabolism
MH  - Sciatic Nerve/*injuries/*pathology
MH  - Wounds and Injuries
EDAT- 2006/10/14 09:00
MHDA- 2007/01/31 09:00
CRDT- 2006/10/14 09:00
PHST- 2006/10/14 09:00 [pubmed]
PHST- 2007/01/31 09:00 [medline]
PHST- 2006/10/14 09:00 [entrez]
AID - 6770 [pii]
PST - ppublish
SO  - Folia Neuropathol. 2006;44(3):221-7.