PMID- 1703981
OWN - NLM
STAT- MEDLINE
DCOM- 19910314
LR  - 20190516
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 4
IP  - 12B
DP  - 1990 Dec
TI  - Developmentally programmed induction of differentiation inhibiting activity and 
      the control of stem cell populations.
PG  - 2308-18
AB  - Differentiation inhibiting activity/leukemia inhibitory factor (DIA/LIF) is a 
      glycoprotein that controls differentiation of pluripotential stem cells. 
      Alternative transcription generates both diffusible and matrix-associated forms 
      of DIA/LIF. Transcriptional analysis using a sensitive ribonuclease protection 
      assay revealed that the two messages are expressed independently, consistent with 
      the proposition that the two forms of DIA/LIF have distinct biological roles. 
      DIA/LIF expression was found to be activated early during differentiation of 
      embryonic stem (ES) cells, providing a mechanism for feedback regulation of stem 
      cell renewal. Expression of DIA/LIF by mesenchymal cells was shown to be 
      controlled in a paracrine manner by polypeptide regulatory factors. Specific 
      expression of the two forms of DIA/LIF was also demonstrated in the egg 
      cylinder-stage mouse embryo. The combination of cell type-specific and 
      signal-specific regulation enables very precise control over DIA/LIF expression 
      and may represent an important component of the regulatory networks that govern 
      stem cell proliferation and differentiation during mammalian development.
FAU - Rathjen, P D
AU  - Rathjen PD
AD  - Department of Biochemistry, University of Oxford, UK.
FAU - Nichols, J
AU  - Nichols J
FAU - Toth, S
AU  - Toth S
FAU - Edwards, D R
AU  - Edwards DR
FAU - Heath, J K
AU  - Heath JK
FAU - Smith, A G
AU  - Smith AG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Growth Inhibitors)
RN  - 0 (Interleukin-6)
RN  - 0 (Leukemia Inhibitory Factor)
RN  - 0 (Lif protein, mouse)
RN  - 0 (Lymphokines)
RN  - 0 (RNA, Messenger)
RN  - 5688UTC01R (Tretinoin)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - *Cell Differentiation/drug effects
MH  - Cell Line
MH  - Chromatography, Affinity
MH  - Embryo, Mammalian
MH  - Feedback
MH  - *Growth Inhibitors
MH  - *Interleukin-6
MH  - Leukemia Inhibitory Factor
MH  - Lymphokines/*biosynthesis/genetics/isolation & purification
MH  - Mice
MH  - Mice, Inbred Strains
MH  - RNA/genetics/isolation & purification
MH  - RNA, Messenger/genetics
MH  - Transcription, Genetic
MH  - Tretinoin/pharmacology
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
AID - 10.1101/gad.4.12b.2308 [doi]
PST - ppublish
SO  - Genes Dev. 1990 Dec;4(12B):2308-18. doi: 10.1101/gad.4.12b.2308.