PMID- 17040902
OWN - NLM
STAT- MEDLINE
DCOM- 20070227
LR  - 20220310
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 281
IP  - 50
DP  - 2006 Dec 15
TI  - Induction of the heat shock pathway during hypoxia requires regulation of heat 
      shock factor by hypoxia-inducible factor-1.
PG  - 38675-81
AB  - Activation of heat shock proteins (Hsps) is critical to adaptation to low oxygen 
      levels (hypoxia) and for enduring the oxidative stress of reoxygenation. Hsps are 
      known to be regulated by heat shock factor (Hsf), but our results demonstrate an 
      unexpected regulatory link between the oxygen-sensing and heat shock pathways. 
      Hsf transcription is up-regulated during hypoxia due to direct binding by 
      hypoxia-inducible factor-1 (HIF-1) to HIF-1 response elements in an Hsf intron. 
      This increase in Hsf transcripts is necessary for full Hsp induction during 
      hypoxia and reoxygenation. The HIF-1-dependent increase in Hsps has a functional 
      impact, as reduced production of Hsps decreases viability of adult flies exposed 
      to hypoxia and reoxygenation. Thus, HIF-1 control of Hsf transcriptional levels 
      is a regulatory mechanism for sensitizing heat shock pathway activity in order to 
      maximize production of protective Hsps. This cross-regulation represents a 
      mechanism by which the low oxygen response pathway has assimilated complex new 
      functions by regulating the key transcriptional activator of the heat shock 
      pathway.
FAU - Baird, Nathan A
AU  - Baird NA
AD  - Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
FAU - Turnbull, Douglas W
AU  - Turnbull DW
FAU - Johnson, Eric A
AU  - Johnson EA
LA  - eng
GR  - T32 HD007348/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061013
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Heat Shock Transcription Factors)
RN  - 0 (Hsf protein, Drosophila)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - DNA
MH  - DNA-Binding Proteins/genetics/*physiology
MH  - Drosophila Proteins/genetics/*physiology
MH  - Drosophila melanogaster
MH  - Heat Shock Transcription Factors
MH  - Hypoxia-Inducible Factor 1/*physiology
MH  - Molecular Sequence Data
MH  - RNA, Messenger/genetics
MH  - Sequence Homology, Nucleic Acid
MH  - Transcription Factors/genetics/*physiology
EDAT- 2006/10/17 09:00
MHDA- 2007/02/28 09:00
CRDT- 2006/10/17 09:00
PHST- 2006/10/17 09:00 [pubmed]
PHST- 2007/02/28 09:00 [medline]
PHST- 2006/10/17 09:00 [entrez]
AID - S0021-9258(20)71859-4 [pii]
AID - 10.1074/jbc.M608013200 [doi]
PST - ppublish
SO  - J Biol Chem. 2006 Dec 15;281(50):38675-81. doi: 10.1074/jbc.M608013200. Epub 2006 
      Oct 13.