PMID- 17041358
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20070710
LR  - 20191110
IS  - 1076-1608 (Print)
IS  - 1076-1608 (Linking)
VI  - 8
IP  - 4
DP  - 2002 Aug
TI  - Central nervous system compromise in primary Sjogren's syndrome.
PG  - 189-96
AB  - Central nervous system (CNS) involvement in primary Sjogren's syndrome (SS) is 
      poorly understood, and its frequency as well as its manifestations are subjects 
      of controversy. The current study was undertaken to determine the prevalence and 
      the clinical and immunogenetic characteristics of CNS compromise in a well 
      defined group of patients with primary SS. In this retrospective study, patients 
      fulfilled the European classification criteria. Among 120 patients with primary 
      SS, 3 (2.5%) had CNS compromise (multiple sclerosis-like illness, complicated 
      migraine, and optic neuritis with epilepsy). The CNS involvement coincided with 
      the onset of sicca symptoms in 1 case. All 3 patients carried the human leukocyte 
      antigen (HLA) DQB1*0303 allele and tested positive for anti-Ro antibodies, but 
      not for anti-cardiolipin antibodies. Although rare, CNS compromise in primary SS 
      can be the presenting manifestation of the disease in a few cases, and may be 
      severe and varied.
FAU - Anaya, Juan-Manuel
AU  - Anaya JM
AD  - Rheumatology Unit, Corporacion para Investigaciones Biologicas, Medellin, 
      Colombia.
FAU - Villa, Luis A
AU  - Villa LA
FAU - Restrepo, Lucas
AU  - Restrepo L
FAU - Molina, Jose F
AU  - Molina JF
FAU - Mantilla, Ruben D
AU  - Mantilla RD
FAU - Vargas, Sergio
AU  - Vargas S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Rheumatol
JT  - Journal of clinical rheumatology : practical reports on rheumatic & 
      musculoskeletal diseases
JID - 9518034
EDAT- 2006/10/17 09:00
MHDA- 2006/10/17 09:01
CRDT- 2006/10/17 09:00
PHST- 2006/10/17 09:00 [pubmed]
PHST- 2006/10/17 09:01 [medline]
PHST- 2006/10/17 09:00 [entrez]
AID - 00124743-200208000-00002 [pii]
AID - 10.1097/00124743-200208000-00002 [doi]
PST - ppublish
SO  - J Clin Rheumatol. 2002 Aug;8(4):189-96. doi: 10.1097/00124743-200208000-00002.