PMID- 17043297
OWN - NLM
STAT- MEDLINE
DCOM- 20061027
LR  - 20220331
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Print)
IS  - 0022-3050 (Linking)
VI  - 77
IP  - 11
DP  - 2006 Nov
TI  - Increased cerebrospinal fluid and serum levels of S100B in first-onset 
      schizophrenia are not related to a degenerative release of glial fibrillar acidic 
      protein, myelin basic protein and neurone-specific enolase from glia or neurones.
PG  - 1284-7
AB  - OBJECTIVE: To assess levels of glial fibrillar acidic protein (GFAP), myelin 
      basic protein (MBP), neurone-specific enolase (NSE) and S100B in patients with 
      first-onset schizophrenia. METHOD: We investigated CSF and serum samples from 12 
      patients with first-onset schizophrenia and from 17 control subjects by ELISA 
      (GFAP, MBP) or immunoluminometric sandwich assays (NSE, S100B). RESULTS: Patients 
      with schizophrenia had significantly higher levels of S100B in CSF (p = 0.004; 
      2.73 (SD 0.80) v 1.92 (0.58) microg/l) and serum (p = 0.032; 0.09 (0.03) v 0.08 
      (0.02) microg/l) in comparison with those in the matched control group. No 
      diagnosis-dependent differences of protein concentration were seen for GFAP, MBP 
      and NSE. DISCUSSION: Our finding of increased levels of S100B in patients with 
      schizophrenia without an indication for significant glial (GFAP, MBP) or neuronal 
      (NSE) damage may be interpreted as indirect evidence for increased active 
      secretion of S100B during acute psychosis.
FAU - Steiner, J
AU  - Steiner J
AD  - Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D-39120 
      Magdeburg, Germany. johann.steiner@medizin.uni-magdeburg.de
FAU - Bielau, H
AU  - Bielau H
FAU - Bernstein, H-G
AU  - Bernstein HG
FAU - Bogerts, B
AU  - Bogerts B
FAU - Wunderlich, M T
AU  - Wunderlich MT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100 Proteins)
RN  - 0 (S100B protein, human)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glial Fibrillary Acidic Protein/blood/cerebrospinal fluid
MH  - Humans
MH  - Male
MH  - Myelin Basic Protein/blood/cerebrospinal fluid
MH  - Nerve Growth Factors/*blood/*cerebrospinal fluid
MH  - Neuroglia/metabolism
MH  - Neurons/metabolism
MH  - Phosphopyruvate Hydratase/blood/cerebrospinal fluid
MH  - S100 Calcium Binding Protein beta Subunit
MH  - S100 Proteins/*blood/*cerebrospinal fluid
MH  - Schizophrenia/*physiopathology
PMC - PMC2077376
COIS- Competing interests: None.
EDAT- 2006/10/18 09:00
MHDA- 2006/10/28 09:00
PMCR- 2009/11/01
CRDT- 2006/10/18 09:00
PHST- 2006/10/18 09:00 [pubmed]
PHST- 2006/10/28 09:00 [medline]
PHST- 2006/10/18 09:00 [entrez]
PHST- 2009/11/01 00:00 [pmc-release]
AID - 77/11/1284 [pii]
AID - jn93427 [pii]
AID - 10.1136/jnnp.2006.093427 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2006 Nov;77(11):1284-7. doi: 
      10.1136/jnnp.2006.093427.