PMID- 17044032
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20091119
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 84
IP  - 8
DP  - 2006 Dec
TI  - Mitogen-activated protein kinase pathway mediates effects of brain-derived 
      neurotrophic factor on differentiation of basal forebrain oligodendrocytes.
PG  - 1692-702
AB  - Previous studies indicate that brain-derived neurotrophic factor (BDNF), through 
      the mediation of the trkB receptor, modulates the expression of differentiated 
      traits in basal forebrain (BF) oligodendrocytes (OLGs). Specifically, BDNF 
      up-regulates the expression of myelin basic protein (MBP), proteolipid protein 
      (PLP), and myelin associated glycoprotein (MAG; Du et al. [2006] Mol. Cell. 
      Neurosci. 31:366-375). However, the signaling cascades mediating the effects of 
      BDNF have not been defined. The current study employs biochemical and molecular 
      biological approaches to examine the involvements of the mitogen-activated 
      protein kinase (MAPK) pathway, the phosphatidylinositol-3 kinase (PI3K) pathway, 
      and the phospholipase C-gamma (PLC-gamma) pathway. Our results indicate that, in 
      BF OLGs, BDNF activates the MAPK pathway and the PLC-gamma pathway but not the 
      PI3K-Akt signaling cascade. By using specific inhibitors and mutated dominant 
      negative or constitutively active forms of MAPK kinase, we demonstrate that the 
      MAPK pathway is mediating the effects of BDNF on expression of differentiated 
      traits in BF OLGs.
FAU - Du, Yangzhou
AU  - Du Y
AD  - Department of Neuroscience and Cell Biology, UMDNJ/Robert Wood Johnson Medical 
      School, Piscataway, NJ 08854, USA.
FAU - Lercher, Lauren D
AU  - Lercher LD
FAU - Zhou, Renping
AU  - Zhou R
FAU - Dreyfus, Cheryl F
AU  - Dreyfus CF
LA  - eng
GR  - 36647/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Estrenes)
RN  - 0 (Pyrrolidinones)
RN  - 112648-68-7 
      (1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Adenoviridae/physiology
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Blotting, Western/methods
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cell Differentiation/*drug effects
MH  - Cells, Cultured
MH  - Enzyme Inhibitors/pharmacology
MH  - Estrenes/pharmacology
MH  - Female
MH  - Immunohistochemistry/methods
MH  - Mitogen-Activated Protein Kinase Kinases/*metabolism
MH  - Oligodendroglia/*drug effects
MH  - Pregnancy
MH  - Prosencephalon/*cytology
MH  - Pyrrolidinones/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/*physiology
MH  - Time Factors
MH  - Transcription, Genetic
EDAT- 2006/10/18 09:00
MHDA- 2007/03/14 09:00
CRDT- 2006/10/18 09:00
PHST- 2006/10/18 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2006/10/18 09:00 [entrez]
AID - 10.1002/jnr.21080 [doi]
PST - ppublish
SO  - J Neurosci Res. 2006 Dec;84(8):1692-702. doi: 10.1002/jnr.21080.