PMID- 17044097
OWN - NLM
STAT- MEDLINE
DCOM- 20070227
LR  - 20200930
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 144B
IP  - 1
DP  - 2007 Jan 5
TI  - Family-based association study between brain-derived neurotrophic factor gene 
      polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese 
      samples.
PG  - 83-6
AB  - Brain-derived neurotrophic factor (BDNF) plays an important role in normal 
      neuronal development. Several lines of evidence implicate the involvement of BDNF 
      in attention-deficit hyperactivity disorder (ADHD). This study investigated the 
      role of two common BDNF variants (Val66Met, C270T) in two samples of ADHD 
      probands from the United Kingdom (n = 180) and Taiwan (n = 212). We found 
      evidence of increased transmission of the C allele of the C270T in Taiwanese 
      samples (TDT: chi(2) = 6.78, P = 0.009) and the two samples pooled together (TDT: 
      chi(2) = 7.24, P = 0.007). No association was found between the Val66Met 
      polymorphism and ADHD in either of the two populations. Analysis of haplotypes 
      demonstrated a significant decreased transmission of haplotypes containing the 
      Val66 allele and the 270T allele in the Taiwanese samples (TDT: chi(2) = 4.57, P 
      = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P = 0.016). This study 
      provides evidence for the possible involvement of BDNF in susceptibility to ADHD.
FAU - Xu, Xiaohui
AU  - Xu X
AD  - MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, 
      King's College London, London, UK. x.xu@iop.kcl.ac.uk
FAU - Mill, Jonathan
AU  - Mill J
FAU - Zhou, Kaixin
AU  - Zhou K
FAU - Brookes, Keeley
AU  - Brookes K
FAU - Chen, Chih-Ken
AU  - Chen CK
FAU - Asherson, Philip
AU  - Asherson P
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Amino Acid Substitution
MH  - Attention Deficit Disorder with Hyperactivity/*genetics/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Parents
MH  - Polymorphism, Single Nucleotide
MH  - Taiwan
MH  - United Kingdom
EDAT- 2006/10/18 09:00
MHDA- 2007/02/28 09:00
CRDT- 2006/10/18 09:00
PHST- 2006/10/18 09:00 [pubmed]
PHST- 2007/02/28 09:00 [medline]
PHST- 2006/10/18 09:00 [entrez]
AID - 10.1002/ajmg.b.30406 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):83-6. doi: 
      10.1002/ajmg.b.30406.