PMID- 17044652
OWN - NLM
STAT- MEDLINE
DCOM- 20061218
LR  - 20180608
IS  - 0895-3988 (Print)
IS  - 0895-3988 (Linking)
VI  - 19
IP  - 4
DP  - 2006 Aug
TI  - Association of angiotensin converting enzyme gene I/D polymorphism with type 2 
      diabetes mellitus.
PG  - 323-7
AB  - OBJECTIVE: To investigate the association of angiotensin converting enzyme (ACE) 
      gene insertion/deletion (I/D) polymorphism with type 2 diabetes mellitus (T2DM). 
      METHODS: Two hundred and nine patients with T2DM diagnosed based on the criteria 
      for diabetes mellitus in 1999 by WHO and 221 controls were recruited from general 
      population of Dongcheng District in Beijing. All subjects were genotyped for the 
      I/D polymorphism of ACE gene by PCR-fragment length polymorphism (FLP) assay. 
      Blood pressure, levels of plasma glucose, lipids and serum insulin were 
      determined. Body mass index (BMI), waist-hip ratio (WHR) and homeostasis model 
      assessment-insulin resistance index (HOMA-IR) were calculated. RESULTS: The 
      genotype frequencies for ACE genes DD, ID, and II were 19.1%, 42.1%, and 38.8% in 
      patients, respectively, and 9.6%, 49.4%, and 41.0% in controls, respectively. The 
      ACE DD genotype frequency was significantly higher in patients than in controls 
      (chi2 = 7.61, P = 0.022). Multivariate logistic regression analysis showed that 
      the ACE DD genotype was a risk factor for T2DM, with the OR of 2.35 (95% CI 
      1.17-4.71) adjusted for age, sex, BMI, WHR, blood pressure, and serum cholesterol 
      levels. CONCLUSION: The ACE DD genotype is associated with the increased 
      susceptibility to type 2 diabetes mellitus.
FAU - Yang, Min
AU  - Yang M
AD  - Department of Endocrinology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences, Beijing 100730, China.
FAU - Qiu, Chang-Chun
AU  - Qiu CC
FAU - Xu, Qun
AU  - Xu Q
FAU - Xiang, Hong-Ding
AU  - Xiang HD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - *Polymorphism, Genetic
MH  - Risk Factors
EDAT- 2006/10/19 09:00
MHDA- 2006/12/19 09:00
CRDT- 2006/10/19 09:00
PHST- 2006/10/19 09:00 [pubmed]
PHST- 2006/12/19 09:00 [medline]
PHST- 2006/10/19 09:00 [entrez]
PST - ppublish
SO  - Biomed Environ Sci. 2006 Aug;19(4):323-7.