PMID- 17044998
OWN - NLM
STAT- MEDLINE
DCOM- 20071227
LR  - 20061018
IS  - 0253-3766 (Print)
IS  - 0253-3766 (Linking)
VI  - 28
IP  - 5
DP  - 2006 May
TI  - [Molecular cytogenetic characteristics of chronic lymphocytic leukemia].
PG  - 349-52
AB  - OBJECTIVE: To explore the molecular cytogenetic characteristics in patients with 
      chronic lymphocytic leukemia (CLL). METHODS: Interphase fluorescence in situ 
      hybridization (FISH) was used to detect trisomy 12, deletion of 13q14 and 17p13 
      in 60 patients with CLL. RESULTS: Out of the 60 patients, 41 (68.3%) had at least 
      one kind of molecular cytogenetic aberrations. Two (3.3%) had two kinds of 
      abnormalities. Trisomy 12 was found in 12 (20.0%) cases, 13q14 deletion in 24 
      (40.0%) cases and 17p13 deletion in 5 (11.7%) cases. The number of trisomy 12 
      cells ranged from 4.0% to 34.0%, 13q14 deletion ranged from 22.0% to 93.0% and 
      17p13 deletion ranged from 6.0% to 68.0%. There was no significant difference 
      among each Binet stages. CONCLUSION: FISH is a more rapid, accurate and sensitive 
      technique in analysis of chromosome aberrations in CLL. FISH may provide accurate 
      information of molecular cytogenetics for CLL.
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Hematology, 1st Affiliated Hospital of Nanjing Medical University, 
      Nanjing 210029, China.
FAU - Li, Jian-yong
AU  - Li JY
FAU - Pan, Jin-lan
AU  - Pan JL
FAU - Qiu, Hai-rong
AU  - Qiu HR
FAU - Shen, Yun-feng
AU  - Shen YF
FAU - Xiao, Bing
AU  - Xiao B
FAU - Chen, Li-juan
AU  - Chen LJ
FAU - Wu, Ya-fang
AU  - Wu YF
FAU - Sheng, Rui-lan
AU  - Sheng RL
FAU - Xue, Yong-quan
AU  - Xue YQ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Zhong Liu Za Zhi
JT  - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JID - 7910681
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 13
MH  - *Chromosomes, Human, Pair 17
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Trisomy
EDAT- 2006/10/19 09:00
MHDA- 2007/12/28 09:00
CRDT- 2006/10/19 09:00
PHST- 2006/10/19 09:00 [pubmed]
PHST- 2007/12/28 09:00 [medline]
PHST- 2006/10/19 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Zhong Liu Za Zhi. 2006 May;28(5):349-52.