PMID- 1704529
OWN - NLM
STAT- MEDLINE
DCOM- 19910319
LR  - 20190726
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 13
IP  - 12 Pt 2
DP  - 1990 Dec
TI  - PR interval behavior during exercise: implications for physiological pacemakers.
PG  - 1719-23
AB  - The relationship between heart rate response and the dynamic changes in the PR 
      interval was assessed in 631 patients undergoing routine cardiac exercise tests 
      for a variety of clinical indications. Patients were stratified into four 
      subsets: nonmedicated normals (n = 437), patients on beta-antagonist agents (n = 
      118), those on antiarrhythmic agents alone (n = 61) and those with a clinical 
      diagnosis of advanced (New York Heart Association [NYHA] Class III or IV) 
      congestive heart failure. All patients were in stable sinus rhythm throughout the 
      test. PR intervals were measured at rest, at mid-exercise and at peak exercise. 
      Mean PR intervals shortened to a statistically significant degree in most 
      subgroups. This effect was predominantly observed in the earlier stages of 
      exercise. In patients with advanced heart failure, there was no statistically 
      significant shortening of exercise PR intervals later in exercise, demonstrating 
      a parallel with their relatively blunted heart rate response. These changes in 
      exercise PR intervals suggest that implanted pacemaker algorithms may be 
      constructed to maximize hemodynamic benefit in patients requiring physiological 
      pacemakers.
FAU - Luceri, R M
AU  - Luceri RM
AD  - Interventional Cardiac Arrhythmia Center, Holy Cross Hospital, Fort Lauderdale, 
      Florida.
FAU - Brownstein, S L
AU  - Brownstein SL
FAU - Vardeman, L
AU  - Vardeman L
FAU - Goldstein, S
AU  - Goldstein S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Anti-Arrhythmia Agents)
SB  - IM
MH  - Adolescent
MH  - Adrenergic beta-Antagonists/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Arrhythmia Agents/*therapeutic use
MH  - Child
MH  - *Electrocardiography/drug effects
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/*physiopathology
MH  - Heart Rate/drug effects/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pacemaker, Artificial
MH  - Physical Exertion/*physiology
MH  - Retrospective Studies
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
AID - 10.1111/j.1540-8159.1990.tb06878.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 1990 Dec;13(12 Pt 2):1719-23. doi: 
      10.1111/j.1540-8159.1990.tb06878.x.