PMID- 17046026
OWN - NLM
STAT- MEDLINE
DCOM- 20070208
LR  - 20131121
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 80
IP  - 4
DP  - 2007 Jan 2
TI  - Dorsal hippocampal dopamine receptors are involved in mediating ethanol 
      state-dependent memory.
PG  - 285-92
AB  - In the present study, the effects of bilateral injections of dopaminergic agents 
      into the hippocampal CA1 regions (intra-CA1) on ethanol (EtOH) state-dependent 
      memory were examined in mice. A single-trial step-down passive avoidance task was 
      used for the assessment of memory retention in adult male NMRI mice. Pre-training 
      intra-peritoneal (i.p.) administration of EtOH (0.25, 0.5 and 1 g/kg) dose 
      dependently induced impairment of memory retention. Pre-test administration of 
      EtOH (0.5 g/kg)-induced state-dependent retrieval of the memory acquired under 
      pre-training EtOH (0.5 g/kg) influence. Intra-CA1 administration of the dopamine 
      D(1) receptor agonist, SKF 38393 (0.5, 1 and 2 g/mouse) or the dopamine D(2) 
      receptor agonist, quinpirole (0.25, 0.5 and 1 microg/mouse) alone cannot affect 
      memory retention. While, pre-test intra-CA1 injection of SKF 38393 (2 
      microg/mouse, intra-CA1) or quinpirole (0.25, 0.5 and 1 microg/mouse, intra-CA1) 
      improved pre-training EtOH (0.5 g/kg)-induced retrieval impairment. Moreover, 
      pre-test administration of SKF 38393 (0.5, 1 and 2 microg/mouse, intra-CA1) or 
      quinpirole (0.5 and 1 microg/mouse, intra-CA1) with an ineffective dose of EtOH 
      (0.25 g/kg) significantly restored the retrieval and induced EtOH state-dependent 
      memory. Furthermore, pre-training injection of the dopamine D(1) receptor 
      antagonist, SCH 23390 (4 microg/mouse), but not the dopamine D(2) receptor 
      antagonist, sulpiride, into the CA1 regions suppressed the learning of a 
      single-trial passive avoidance task. Pre-test intra-CA1 injection of SCH 23390 (2 
      and 4 microg/mouse, intra-CA1) or sulpiride (2.5 and 5 microg/mouse, intra-CA1) 5 
      min before the administration of EtOH (0.5 g/kg, i.p.) dose dependently inhibited 
      EtOH state-dependent memory. These findings implicate the involvement of a dorsal 
      hippocampal dopaminergic mechanism in EtOH state-dependent memory and also it can 
      be concluded that there may be a cross-state dependency between EtOH and 
      dopamine.
FAU - Rezayof, Ameneh
AU  - Rezayof A
AD  - School of Biology, University College of Science, University of Tehran, Tehran, 
      Iran.
FAU - Motevasseli, Tahmineh
AU  - Motevasseli T
FAU - Rassouli, Yassaman
AU  - Rassouli Y
FAU - Zarrindast, Mohammad-Reza
AU  - Zarrindast MR
LA  - eng
PT  - Journal Article
DEP - 20060923
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - 20OP60125T (Quinpirole)
RN  - 3K9958V90M (Ethanol)
RN  - 67287-49-4 (2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine)
RN  - 7MNE9M8287 (Sulpiride)
SB  - IM
MH  - 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Central Nervous System Depressants/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - Ethanol/*pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Male
MH  - Memory/*drug effects
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Quinpirole/pharmacology
MH  - Receptors, Dopamine D1/agonists/*metabolism
MH  - Receptors, Dopamine D2/agonists/metabolism
MH  - Sulpiride/pharmacology
MH  - Time Factors
EDAT- 2006/10/19 09:00
MHDA- 2007/02/09 09:00
CRDT- 2006/10/19 09:00
PHST- 2006/05/21 00:00 [received]
PHST- 2006/09/11 00:00 [revised]
PHST- 2006/09/13 00:00 [accepted]
PHST- 2006/10/19 09:00 [pubmed]
PHST- 2007/02/09 09:00 [medline]
PHST- 2006/10/19 09:00 [entrez]
AID - S0024-3205(06)00719-3 [pii]
AID - 10.1016/j.lfs.2006.09.013 [doi]
PST - ppublish
SO  - Life Sci. 2007 Jan 2;80(4):285-92. doi: 10.1016/j.lfs.2006.09.013. Epub 2006 Sep 
      23.