PMID- 17046733
OWN - NLM
STAT- MEDLINE
DCOM- 20070226
LR  - 20070103
IS  - 0009-9120 (Print)
IS  - 0009-9120 (Linking)
VI  - 40
IP  - 1-2
DP  - 2007 Jan
TI  - Impaired renal function and duration of dialysis therapy are associated with 
      oxidative stress and proatherogenic cytokine levels in patients with end-stage 
      renal disease.
PG  - 81-5
AB  - OBJECTIVES: The present study was undertaken to clarify the role of the impaired 
      renal function and the dialysis therapy on plasma levels of proatherogenic 
      cytokines and Cu/Zn superoxide dismutase (Cu/Zn SOD)--as a marker of oxidative 
      stress (SOX) in uraemia. DESIGN AND METHODS: We have measured the levels of Cu/Zn 
      SOD, monocyte chemoattractant protein-1 (MCP-1) macrophage inflammatory proteins 
      (MIP-1alpha, MIP-1beta) and vascular endothelial growth factor (VEGF) in the 
      plasma of predialysis (CRF) (n=42), on maintenance hemodialysis (HD) (n=25) or 
      peritoneal dialysis (PD) (n=45) patients and in the healthy volunteers (n=20). 
      RESULTS: The increase in Cu/Zn SOD levels was in PD and HD patients compared to 
      controls (215.56+/-125.18 and 356.28+/-122.57 versus 53.53+/-23.65 ng/ml, 
      respectively). In plasma of the CRF, PD and HD subjects we have also observed the 
      significant increase in the levels of MIP-1beta: [31.5 (2-149), 33.0 (1-203) and 
      76.0 (9-345), respectively]; MCP-1 (616.50+/-240.15, 943.64+/-348.99 and 
      968.50+/-355.85, respectively) and VEGF (387.93+/-184.63, 371.56+/-125.18 and 
      645.56+/-136.30, respectively) compared to healthy people. In the predialysis 
      group, creatinine clearance correlated with Cu/Zn SOD and cytokine levels. 
      Moreover, the cytokine levels were also associated with age. In dialysis 
      patients, the correlations were between duration of dialysis treatment and both 
      Cu/Zn SOD and cytokine levels. There was also a direct relationship between Cu/Zn 
      SOD and both MIP-1beta and VEGF levels. CONCLUSIONS: This study has shown that 
      impaired renal function, age and duration of dialysis treatment are associated 
      with increased oxidative stress and proatherogenic cytokine levels in uremic 
      patients.
FAU - Pawlak, Krystyna
AU  - Pawlak K
AD  - Department of Nephrology and Clinical Transplantation, Medical University, 14 
      Zurawia St, 15-540 Bialystok, Poland. krystynapawlak@poczta.onet.pl
FAU - Pawlak, Dariusz
AU  - Pawlak D
FAU - Mysliwiec, Michal
AU  - Mysliwiec M
LA  - eng
PT  - Journal Article
DEP - 20060914
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Cytokines)
SB  - IM
MH  - Atherosclerosis/*pathology
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Kidney/*physiopathology
MH  - Kidney Failure, Chronic/*physiopathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Renal Dialysis/*methods
MH  - Time Factors
EDAT- 2006/10/19 09:00
MHDA- 2007/02/27 09:00
CRDT- 2006/10/19 09:00
PHST- 2006/06/06 00:00 [received]
PHST- 2006/08/28 00:00 [revised]
PHST- 2006/09/01 00:00 [accepted]
PHST- 2006/10/19 09:00 [pubmed]
PHST- 2007/02/27 09:00 [medline]
PHST- 2006/10/19 09:00 [entrez]
AID - S0009-9120(06)00277-3 [pii]
AID - 10.1016/j.clinbiochem.2006.09.001 [doi]
PST - ppublish
SO  - Clin Biochem. 2007 Jan;40(1-2):81-5. doi: 10.1016/j.clinbiochem.2006.09.001. Epub 
      2006 Sep 14.