PMID- 17048575
OWN - NLM
STAT- MEDLINE
DCOM- 20070912
LR  - 20181201
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 31
IP  - 15
DP  - 2006 Aug
TI  - [Mechanism of Shenqi compound recipe anti-earlier diabetic artherosclerosis in GK 
      rats].
PG  - 1272-6
AB  - OBJECTIVE: To explore the mechanism of Shenqi compound recipe (SQCR) anti-earlier 
      diabetic artherosclerosis in GK rats. METHOD: Four-month specefic pathogen free 
      (SPF) GK rats were divided randomly according to blood glucose level into four 
      groups: model group (5 mL x kg(-1) x d(-1) sterile water), ramipril group 
      (positive control, 1 mg x kg(-1) x d(-1)), SQCR low dosage (0.72 g x kg(-1) x 
      d(-1)) and SQCR high dosage group (2.88 g x kg(-1) x d(-1)) and Wistar rats as 
      normal control group(5 mL x kg(-1) x d(-1) sterile water). GK rats took high-fat 
      diet freely and meanwile were injected N-omega-nitro-L-arginine methyl ester 
      (L-N-AME) intra-peritoneally with the dose of 10 mg x kg(-1) x d(-1) in order to 
      induce earlier diabetic artherosclerosis, while normal control group took regular 
      diet and were injected normal saline intra-peritoneally. In the experiment 
      periods, each group was administrated correspondent substance respectively for 32 
      d. At the end, sampling blood by abdominal aorta and picking aorta on ice. 
      Determined monocyte chemoattractant protein-1 (MCP-1) concentration by ELISA, 
      messenger ribonucleic acid (mRNA) expression of MCP-1 and peroxisome 
      proliferator-activated receptor gamma (PPARgamma) in aorta by reverse 
      transcriptase PCR (RT-PCR). RESULT: Concentrations of MCP-1 in serum in SQCR low 
      and high dosage groups and the mRNA expression of MCP-1 in SQCR high dosage group 
      were all decreased significantly compared with model group (P < 0.05). The mRNA 
      expression of PPARgamma in SQCR low and high dosage groups all increased compared 
      with model group (P < 0.05 or P < 0.01). CONCLUSION: Inhibiting the mRNA and 
      protein expression of MCP-1 and upregulating the mRNA expression of PPARgamma in 
      aorta might be contribute to SQCR anti-earlier diabetic artherosclerosis in GK 
      rats partly.
FAU - Zhang, Hong-min
AU  - Zhang HM
AD  - Department of Integrated Traditional Chinese and Western Medicine, West China 
      Hospital, Sichuan University, Chengdu.
FAU - Chen, Shi-wei
AU  - Chen SW
FAU - Xie, Chun-guang
AU  - Xie CG
FAU - Xie, Yi-qiang
AU  - Xie YQ
FAU - Deng, Xi-fang
AU  - Deng XF
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Drug Combinations)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (PPAR gamma)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Aorta/metabolism
MH  - Astragalus propinquus/chemistry
MH  - Atherosclerosis/etiology/*metabolism
MH  - Chemokine CCL2/*biosynthesis/blood/genetics
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Drug Combinations
MH  - Drugs, Chinese Herbal/isolation & purification/*pharmacology
MH  - Male
MH  - PPAR gamma/biosynthesis/genetics
MH  - Panax/chemistry
MH  - *Plants, Medicinal/chemistry
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
EDAT- 2006/10/20 09:00
MHDA- 2007/09/13 09:00
CRDT- 2006/10/20 09:00
PHST- 2006/10/20 09:00 [pubmed]
PHST- 2007/09/13 09:00 [medline]
PHST- 2006/10/20 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2006 Aug;31(15):1272-6.