PMID- 17048979
OWN - NLM
STAT- MEDLINE
DCOM- 20070108
LR  - 20240323
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Print)
IS  - 1549-1277 (Linking)
VI  - 3
IP  - 10
DP  - 2006 Oct
TI  - Anatomical alterations of the visual motion processing network in migraine with 
      and without aura.
PG  - e402
LID - e402
AB  - BACKGROUND: Patients suffering from migraine with aura (MWA) and migraine without 
      aura (MWoA) show abnormalities in visual motion perception during and between 
      attacks. Whether this represents the consequences of structural changes in 
      motion-processing networks in migraineurs is unknown. Moreover, the diagnosis of 
      migraine relies on patient's history, and finding differences in the brain of 
      migraineurs might help to contribute to basic research aimed at better 
      understanding the pathophysiology of migraine. METHODS AND FINDINGS: To 
      investigate a common potential anatomical basis for these disturbances, we used 
      high-resolution cortical thickness measurement and diffusion tensor imaging (DTI) 
      to examine the motion-processing network in 24 migraine patients (12 with MWA and 
      12 MWoA) and 15 age-matched healthy controls (HCs). We found increased cortical 
      thickness of motion-processing visual areas MT+ and V3A in migraineurs compared 
      to HCs. Cortical thickness increases were accompanied by abnormalities of the 
      subjacent white matter. In addition, DTI revealed that migraineurs have 
      alterations in superior colliculus and the lateral geniculate nucleus, which are 
      also involved in visual processing. CONCLUSIONS: A structural abnormality in the 
      network of motion-processing areas could account for, or be the result of, the 
      cortical hyperexcitability observed in migraineurs. The finding in patients with 
      both MWA and MWoA of thickness abnormalities in area V3A, previously described as 
      a source in spreading changes involved in visual aura, raises the question as to 
      whether a "silent" cortical spreading depression develops as well in MWoA. In 
      addition, these experimental data may provide clinicians and researchers with a 
      noninvasively acquirable migraine biomarker.
FAU - Granziera, Cristina
AU  - Granziera C
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of 
      America.
FAU - DaSilva, Alexandre F M
AU  - DaSilva AF
FAU - Snyder, Josh
AU  - Snyder J
FAU - Tuch, David S
AU  - Tuch DS
FAU - Hadjikhani, Nouchine
AU  - Hadjikhani N
LA  - eng
GR  - P01 NS035611/NS/NINDS NIH HHS/United States
GR  - U54 EB005149/EB/NIBIB NIH HHS/United States
GR  - 5P01 NS 35611-09/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
CIN - PLoS Med. 2006 Oct;3(10):e404. PMID: 17048980
MH  - Adult
MH  - Brain/*pathology/physiopathology
MH  - Cerebral Cortex/pathology
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Geniculate Bodies/pathology
MH  - Humans
MH  - Male
MH  - Migraine with Aura/diagnosis/*physiopathology
MH  - Migraine without Aura/diagnosis/*physiopathology
MH  - *Motion Perception
MH  - Nerve Net/*pathology/physiopathology
MH  - Superior Colliculi/pathology
MH  - *Visual Perception
PMC - PMC1609120
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2006/10/20 09:00
MHDA- 2007/01/09 09:00
PMCR- 2006/10/17
CRDT- 2006/10/20 09:00
PHST- 2006/02/23 00:00 [received]
PHST- 2006/07/31 00:00 [accepted]
PHST- 2006/10/20 09:00 [pubmed]
PHST- 2007/01/09 09:00 [medline]
PHST- 2006/10/20 09:00 [entrez]
PHST- 2006/10/17 00:00 [pmc-release]
AID - 06-PLME-RA-0158R4 [pii]
AID - 10.1371/journal.pmed.0030402 [doi]
PST - ppublish
SO  - PLoS Med. 2006 Oct;3(10):e402. doi: 10.1371/journal.pmed.0030402.