PMID- 17049180
OWN - NLM
STAT- MEDLINE
DCOM- 20070126
LR  - 20191210
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 143
IP  - 1
DP  - 2006 Nov 17
TI  - Nucleus accumbens opioids regulate flavor-based preferences in food consumption.
PG  - 309-17
AB  - Opioid signaling in the nucleus accumbens (NAcc) regulates feeding behavior, 
      having particularly strong effects on consumption of highly palatable foods. 
      Since macronutrient content may contribute to palatability, it is uncertain 
      whether opioid regulation of food consumption is based primarily on its 
      macronutrient content or its flavor per se. In order to isolate the effect of 
      flavor, we manipulated opioid signaling in the NAcc in rats and quantified 
      consumption of differently flavored but nutritionally identical pellets. When 
      pellets of either flavor were presented alone, microinjection of 
      d-Ala(2),N,Me-Phe(4),Gly-ol(5)-enkephalin (DAMGO (a mu opioid receptor (MOP) 
      agonist)) into the NAcc increased consumption of pellets of both flavors equally. 
      When both flavors of pellets were presented simultaneously, however, DAMGO in the 
      NAcc selectively increased, while naltrexone (a non-selective opioid antagonist) 
      in the NAcc selectively decreased, consumption of the more preferred flavor. 
      Systemic naltrexone injection had no flavor specific effects, decreasing 
      consumption of both flavors equally. Non-selective inactivation of NAcc neurons 
      by local microinjection of muscimol (a GABA(A) agonist) increased consumption of 
      both the more- and less-preferred flavors equally. These results indicate that 
      opioid signaling directly regulates a subset of NAcc neurons that can selectively 
      enhance consumption of preferred palatable foods based exclusively on flavor 
      cues.
FAU - Woolley, J D
AU  - Woolley JD
AD  - The Ernest Gallo Clinic and Research Center and the Wheeler Center for the 
      Neurobiology of Addiction, Department of Neurology, University of California, San 
      Francisco, San Francisco, CA 94143, USA.
FAU - Lee, B S
AU  - Lee BS
FAU - Fields, H L
AU  - Fields HL
LA  - eng
GR  - R25 MH060482/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Flavoring Agents)
RN  - 0 (Narcotic Antagonists)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 5S6W795CQM (Naltrexone)
SB  - IM
MH  - Analgesics, Opioid/*metabolism/pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Eating/drug effects/*physiology
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology
MH  - Feeding Behavior/*drug effects
MH  - Flavoring Agents/pharmacology
MH  - Male
MH  - Naltrexone/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Nucleus Accumbens/drug effects/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - *Reinforcement, Psychology
MH  - Time Factors
EDAT- 2006/10/20 09:00
MHDA- 2007/01/27 09:00
CRDT- 2006/10/20 09:00
PHST- 2006/05/02 00:00 [received]
PHST- 2006/06/25 00:00 [revised]
PHST- 2006/06/27 00:00 [accepted]
PHST- 2006/10/20 09:00 [pubmed]
PHST- 2007/01/27 09:00 [medline]
PHST- 2006/10/20 09:00 [entrez]
AID - S0306-4522(06)00924-9 [pii]
AID - 10.1016/j.neuroscience.2006.06.067 [doi]
PST - ppublish
SO  - Neuroscience. 2006 Nov 17;143(1):309-17. doi: 10.1016/j.neuroscience.2006.06.067.