PMID- 17049442
OWN - NLM
STAT- MEDLINE
DCOM- 20070605
LR  - 20151119
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 101
IP  - 5
DP  - 2007 May
TI  - The relation of adult bronchial responsiveness to serious childhood respiratory 
      illness in the ECRHS.
PG  - 983-8
AB  - BACKGROUND: Respiratory symptoms in adulthood have been found to be associated 
      with childhood respiratory infection, but few studies have analyzed adult 
      bronchial responsiveness (BHR) with adequate adjustment for known risk factors. 
      OBJECTIVE: To estimate the relation of BHR with serious childhood respiratory 
      infections in a large population study. METHODS: The European Community 
      Respiratory Health Survey (ECRHS) was a cross-sectional population-based survey 
      in 34 centers. Data on serious respiratory infections before the age of 5 years 
      and possible confounders were obtained from a questionnaire administered in the 
      clinic. Blood samples were taken for measurement of total immunoglobulin E (IgE) 
      and specific IgE to four common allergens, and spirometry and bronchial challenge 
      with methacholine were performed. A continuous measure of BHR was analyzed by 
      multiple regression, in 11,282 participants, in relation to serious respiratory 
      infection and other potential risk factors, adjusted for center and major 
      determinants of adult BHR. RESULTS: Those reporting a serious childhood 
      respiratory infection had greater BHR, by an amount corresponding to 
      approximately 0.23 doubling doses (95% confidence interval 0.02-0.44) of the 
      amount of methacholine causing a 20% fall (PD(20)) in forced expiratory volume in 
      1s (FEV(1)). All childhood factors explained less than 0.3% of variation in BHR 
      in addition to over 20% by factors measured in adulthood. The relation of BHR to 
      BMI was confined to smokers. CONCLUSIONS: We found an effect of serious childhood 
      respiratory infection on adult BHR, but this was small in comparison to relations 
      of BHR to IgE-sensitization and airway caliber.
FAU - Chinn, Susan
AU  - Chinn S
AD  - Department Public Health Sciences, King's College London, 5th floor Capital 
      House, 42 Weston Street, London SE1 3QD, UK. s.chinn@imperial.ac.uk
FAU - Janson, Christer
AU  - Janson C
FAU - Svanes, Cecilie
AU  - Svanes C
FAU - Dharmage, Shyamali
AU  - Dharmage S
FAU - Jarvis, Deborah
AU  - Jarvis D
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20061016
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Body Mass Index
MH  - Bronchial Hyperreactivity/epidemiology/*etiology/physiopathology
MH  - Bronchoconstrictor Agents
MH  - Cross-Sectional Studies
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Methacholine Chloride
MH  - Respiratory Tract Infections/*complications/epidemiology/physiopathology
MH  - Risk Factors
MH  - Smoking/adverse effects
MH  - Vital Capacity
EDAT- 2006/10/20 09:00
MHDA- 2007/06/06 09:00
CRDT- 2006/10/20 09:00
PHST- 2006/05/22 00:00 [received]
PHST- 2006/08/18 00:00 [revised]
PHST- 2006/09/05 00:00 [accepted]
PHST- 2006/10/20 09:00 [pubmed]
PHST- 2007/06/06 09:00 [medline]
PHST- 2006/10/20 09:00 [entrez]
AID - S0954-6111(06)00446-X [pii]
AID - 10.1016/j.rmed.2006.09.004 [doi]
PST - ppublish
SO  - Respir Med. 2007 May;101(5):983-8. doi: 10.1016/j.rmed.2006.09.004. Epub 2006 Oct 
      16.