PMID- 17049884
OWN - NLM
STAT- MEDLINE
DCOM- 20070709
LR  - 20240312
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 34
IP  - 1
DP  - 2007 Jan 1
TI  - Sensitivity of the nucleus accumbens to violations in expectation of reward.
PG  - 455-61
AB  - This study examined whether ventral frontostriatal regions differentially code 
      expected and unexpected reward outcomes. We parametrically manipulated the 
      probability of reward and examined the neural response to reward and nonreward 
      for each probability condition in the ventral striatum and the orbitofrontal 
      cortex (OFC). By late trials of the experiment, subjects showed slower behavioral 
      responses for the condition with the lowest probability of reward, relative to 
      the condition with the highest probability of reward. At the neural level, both 
      the nucleus accumbens (NAcc) and OFC showed greater activation to rewarded 
      relative to nonrewarded trials, but the accumbens appeared to be most sensitive 
      to violations in expected reward outcomes. These data suggest distinct roles for 
      frontostriatal circuitry in reward prediction and in responding to violations in 
      expectations.
FAU - Spicer, Julie
AU  - Spicer J
AD  - The Sackler Institute for Developmental Psychobiology, Weill Cornell Medical 
      College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021, 
      USA.
FAU - Galvan, Adriana
AU  - Galvan A
FAU - Hare, Todd A
AU  - Hare TA
FAU - Voss, Henning
AU  - Voss H
FAU - Glover, Gary
AU  - Glover G
FAU - Casey, Bj
AU  - Casey B
LA  - eng
GR  - P50 MH062196/MH/NIMH NIH HHS/United States
GR  - R01 DA018879/DA/NIDA NIH HHS/United States
GR  - R21 DA015882/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20061017
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Nucleus Accumbens/*physiology
MH  - *Reward
PMC - PMC1796943
MID - NIHMS14829
EDAT- 2006/10/20 09:00
MHDA- 2007/07/10 09:00
PMCR- 2008/01/31
CRDT- 2006/10/20 09:00
PHST- 2006/02/27 00:00 [received]
PHST- 2006/09/12 00:00 [revised]
PHST- 2006/09/13 00:00 [accepted]
PHST- 2006/10/20 09:00 [pubmed]
PHST- 2007/07/10 09:00 [medline]
PHST- 2006/10/20 09:00 [entrez]
PHST- 2008/01/31 00:00 [pmc-release]
AID - S1053-8119(06)00944-X [pii]
AID - 10.1016/j.neuroimage.2006.09.012 [doi]
PST - ppublish
SO  - Neuroimage. 2007 Jan 1;34(1):455-61. doi: 10.1016/j.neuroimage.2006.09.012. Epub 
      2006 Oct 17.