PMID- 17049922
OWN - NLM
STAT- MEDLINE
DCOM- 20070412
LR  - 20220318
IS  - 1471-4892 (Print)
IS  - 1471-4892 (Linking)
VI  - 7
IP  - 1
DP  - 2007 Feb
TI  - Role of neurotrophic factors in depression.
PG  - 18-21
AB  - Major depression is associated with reduced volumes in the hippocampus and 
      prefrontal cortex, whereas antidepressant treatments promote several forms of 
      neuronal plasticity, including neurogenesis, synaptogenesis and neuronal 
      maturation, in the hippocampus. Several neurotrophic factors are associated with 
      depression or antidepressant action. Stress suppresses brain-derived neurotrophic 
      factor (BDNF) synthesis in the hippocampus, at least partially through a 
      sustained modification of chromatin structure. Essentially all antidepressant 
      treatments increase BDNF synthesis and signaling in the hippocampus and 
      prefrontal cortex. This signaling is required for the behavioral effects of 
      antidepressant drugs in rodents, and increased BDNF levels in the hippocampus 
      mimic the behavioral effects of antidepressants. However, injection of BDNF into 
      the mesolimbic dopamine pathway produces an opposing depression-like response. 
      One hypothesis emerging from these data proposes that mood disorders reflect 
      failed function of critical neuronal networks, whereas a gradual network recovery 
      through activity-dependent neuronal plasticity induces the antidepressant effect. 
      Neurotrophic factors themselves do not control mood, but they act as necessary 
      tools in the activity-dependent modulation of networks, the physiological 
      function of which determines how a plastic change influences mood.
FAU - Castren, Eero
AU  - Castren E
AD  - Sigrid Juselius Laboratory of Molecular Neuroscience, Neuroscience Center, 
      University of Helsinki, PO Box 56, 00014 Helsinki, Finland. 
      eero.castren@helsinki.fi
FAU - Voikar, Vootele
AU  - Voikar V
FAU - Rantamaki, Tomi
AU  - Rantamaki T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20061017
PL  - England
TA  - Curr Opin Pharmacol
JT  - Current opinion in pharmacology
JID - 100966133
RN  - 0 (Antidepressive Agents)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - Depression/drug therapy/*metabolism
MH  - Humans
MH  - Mood Disorders/metabolism
MH  - Nerve Growth Factors/*metabolism
MH  - Stress, Physiological/metabolism
RF  - 32
EDAT- 2006/10/20 09:00
MHDA- 2007/04/14 09:00
CRDT- 2006/10/20 09:00
PHST- 2006/08/14 00:00 [received]
PHST- 2006/08/14 00:00 [accepted]
PHST- 2006/10/20 09:00 [pubmed]
PHST- 2007/04/14 09:00 [medline]
PHST- 2006/10/20 09:00 [entrez]
AID - S1471-4892(06)00171-8 [pii]
AID - 10.1016/j.coph.2006.08.009 [doi]
PST - ppublish
SO  - Curr Opin Pharmacol. 2007 Feb;7(1):18-21. doi: 10.1016/j.coph.2006.08.009. Epub 
      2006 Oct 17.