PMID- 17049923
OWN - NLM
STAT- MEDLINE
DCOM- 20070327
LR  - 20220129
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 27
IP  - 12
DP  - 2006 Dec
TI  - Stromal-cell regulation of dendritic-cell differentiation and function.
PG  - 580-7
AB  - Dendritic cells (DCs) are the ubiquitous sentinels of the immune system, 
      instructing and shaping the adaptive immune response. As such, DCs are often 
      targeted directly by pathogens as a means of immune evasion. Although DCs in 
      different anatomical locations originate from common bone-marrow-derived 
      progenitors and, hence, share several characteristics, microenvironmental factors 
      have an important influence on DC biology under both steady-state and 
      inflammatory conditions. A growing body of literature suggests that these 
      instructive processes are mediated by tissue stromal cells, empowering these 
      cells with a decisive role in local immune regulation. Here, we review recent 
      progress in this area, focussing on the role of stromal cells in supporting the 
      generation of regulatory DCs, and propose that tissue stromal cells provide an 
      alternate avenue whereby pathogens can influence DC function.
FAU - Svensson, Mattias
AU  - Svensson M
AD  - Center for Infectious Medicine, Department of Medicine, F59, Karolinska 
      Institutet, Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden. 
      mattias.svensson@ki.se
FAU - Kaye, Paul M
AU  - Kaye PM
LA  - eng
GR  - G0400786/MRC_/Medical Research Council/United Kingdom
GR  - G0400786(71636)/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20061017
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Dendritic Cells/*physiology
MH  - Gene Expression Regulation
MH  - Humans
MH  - Mice
MH  - Models, Immunological
MH  - Signal Transduction
MH  - Stromal Cells/*physiology
RF  - 69
EDAT- 2006/10/20 09:00
MHDA- 2007/03/28 09:00
CRDT- 2006/10/20 09:00
PHST- 2006/09/01 00:00 [received]
PHST- 2006/09/25 00:00 [revised]
PHST- 2006/10/05 00:00 [accepted]
PHST- 2006/10/20 09:00 [pubmed]
PHST- 2007/03/28 09:00 [medline]
PHST- 2006/10/20 09:00 [entrez]
AID - S1471-4906(06)00295-X [pii]
AID - 10.1016/j.it.2006.10.006 [doi]
PST - ppublish
SO  - Trends Immunol. 2006 Dec;27(12):580-7. doi: 10.1016/j.it.2006.10.006. Epub 2006 
      Oct 17.