PMID- 17051491
OWN - NLM
STAT- MEDLINE
DCOM- 20061127
LR  - 20220310
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 43
IP  - 10
DP  - 2006 Nov 15
TI  - Proton pump inhibitors and hospitalization for Clostridium difficile-associated 
      disease: a population-based study.
PG  - 1272-6
AB  - BACKGROUND: Previous studies have examined the association between proton pump 
      inhibitor (PPI) use and the risk of Clostridium difficile-associated disease 
      (CDAD), with conflicting results. Whether outpatient PPI use influences the risk 
      of hospital admission for CDAD among older patients who have recently been 
      treated with antibiotics is unknown. METHODS: We conducted a population-based, 
      nested case-control study of linked health care databases in Ontario, Canada, 
      from 1 April 2002 through 31 March 2005. We identified patients aged > or = 66 
      years who were hospitalized for CDAD within 60 days of receiving outpatient 
      antibiotic therapy. Each case patient with CDAD was matched with 10 control 
      subjects on the basis of age, sex, and details of antibiotic use (antibiotic 
      class, timing, and number of antibiotics used). PPI use by case patients and 
      control subjects was categorized as current (within 90 days), recent (91-180 
      days), or remote (181-365 days). We used conditional logistic regression to 
      estimate the odds ratio for the association between outpatient PPI use and risk 
      of hospitalization for CDAD. RESULTS: We identified 1389 case patients and 12,303 
      matched control subjects. Case patients were no more likely than control subjects 
      to have received a PPI in the preceding 90 days (adjusted odds ratio, 0.9; 95% 
      confidence interval, 0.8-1.1). Similarly, we found no association between 
      hospitalization for CDAD and more remote use of PPIs. CONCLUSIONS: Among 
      community-dwelling older patients, PPI use is not a risk factor for 
      hospitalization with CDAD.
FAU - Lowe, Donna O
AU  - Lowe DO
AD  - Department of Pharmacy Services, University Health Network, University of 
      Toronto, ON, M5G 2C4, Canada. donna.lowe@uhn.on.ca
FAU - Mamdani, Muhammad M
AU  - Mamdani MM
FAU - Kopp, Alexander
AU  - Kopp A
FAU - Low, Donald E
AU  - Low DE
FAU - Juurlink, David N
AU  - Juurlink DN
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061013
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Anti-Infective Agents/therapeutic use
MH  - Case-Control Studies
MH  - *Clostridioides difficile
MH  - Enterocolitis, Pseudomembranous/*drug therapy/economics/microbiology
MH  - Female
MH  - *Hospitalization
MH  - Humans
MH  - Male
MH  - *Proton Pump Inhibitors
EDAT- 2006/10/20 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/10/20 09:00
PHST- 2006/04/02 00:00 [received]
PHST- 2006/08/07 00:00 [accepted]
PHST- 2006/10/20 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/10/20 09:00 [entrez]
AID - CID39734 [pii]
AID - 10.1086/508453 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2006 Nov 15;43(10):1272-6. doi: 10.1086/508453. Epub 2006 Oct 
      13.