PMID- 17052209
OWN - NLM
STAT- MEDLINE
DCOM- 20070129
LR  - 20091119
IS  - 0300-5127 (Print)
IS  - 0300-5127 (Linking)
VI  - 34
IP  - Pt 5
DP  - 2006 Nov
TI  - The role of scaffold proteins in MEK/ERK signalling.
PG  - 833-6
AB  - Signal transduction networks allow cells to recognize and respond to changes in 
      the extracellular environment. All eukaryotic cells have MAPK (mitogen-activated 
      protein kinase) pathways that participate in diverse cellular functions, 
      including differentiation, survival, transformation and movement. Five distinct 
      groups of MAPKs have been characterized in mammals, the most extensively studied 
      of which is the Ras/Raf/MEK [MAPK/ERK (extracellular-signal-regulated kinase) 
      kinase]/ERK cascade. Numerous stimuli, including growth factors and phorbol 
      esters, activate MEK/ERK signalling. How disparate extracellular signals are 
      translated by MEK/ERK into different cellular functions remains obscure. 
      Originally identified in yeast, scaffold proteins are now recognized to 
      contribute to the specificity of MEK/ERK pathways in mammalian cells. These 
      scaffolds include KSR (kinase suppressor of Ras), beta-arrestin, MEK partner-1, 
      Sef and IQGAP1. Scaffolds organize multiprotein signalling complexes. This 
      targets MEK/ERK to specific substrates and facilitates communication with other 
      pathways, thereby mediating diverse functions. The adaptor proteins regulate the 
      kinetics, amplitude and localization of MEK/ERK signalling, providing an 
      efficient mechanism that enables an individual extracellular stimulus to promote 
      a specific biological response.
FAU - Sacks, D B
AU  - Sacks DB
AD  - Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 
      Thorn 530, 75 Francis Street, Boston, MA 02115, USA. dsacks@rics.bwh.harvard.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Nuclear Matrix-Associated Proteins)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
SB  - IM
MH  - Animals
MH  - Kinetics
MH  - MAP Kinase Kinase Kinases/*metabolism
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - Models, Biological
MH  - Nuclear Matrix-Associated Proteins/*physiology
MH  - Signal Transduction/*physiology
MH  - Substrate Specificity
EDAT- 2006/10/21 09:00
MHDA- 2007/01/30 09:00
CRDT- 2006/10/21 09:00
PHST- 2006/10/21 09:00 [pubmed]
PHST- 2007/01/30 09:00 [medline]
PHST- 2006/10/21 09:00 [entrez]
AID - BST0340833 [pii]
AID - 10.1042/BST0340833 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2006 Nov;34(Pt 5):833-6. doi: 10.1042/BST0340833.