PMID- 17052360
OWN - NLM
STAT- MEDLINE
DCOM- 20070103
LR  - 20181113
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 6
DP  - 2006 Oct 20
TI  - Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT 
      lymphoma.
PG  - 249
AB  - BACKGROUND: It remains unknown whether primary ocular adnexal extranodal marginal 
      zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a 
      homogeneous entity, as there are few reports of the results of cytogenetic or 
      molecular analyses of these tumors. METHODS: We performed interphase fluorescence 
      in situ hybridization (FISH) analysis to detect translocations and aneuploidy in 
      34 cases of primary ocular adnexal MALT lymphoma, and reviewed the 
      histopathological findings. Correlations between the results of FISH analysis, 
      the histopathological features and the clinical data were also analyzed. RESULTS: 
      Among the 34 cases, FISH analysis revealed t(14;18)(q32;q21) in one case, trisomy 
      3 in 21 cases (62%), and trisomy 18 in 16 cases (47%). The cases with trisomy 18 
      had significantly more prominent lymphoepithelial lesions (LELs) and less 
      nodularity in the tumors. In regard to the clinical correlations, tumors with 
      trisomy 18 were observed predominantly in females and younger patients; also, in 
      the majority of the cases, the tumor was of conjunctival origin. All the cases 
      with recurrence showed trisomy 18 in the tumor. CONCLUSION: Primary ocular 
      adnexal MALT lymphoma is a significantly heterogeneous entity. Cases with trisomy 
      18 may have unique clinicopathological features.
FAU - Tanimoto, Kazuki
AU  - Tanimoto K
AD  - Hematology and Stem Cell Transplantation Division, National Cancer Center 
      Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan. kaztanimo@qmed.hosp.go.jp
FAU - Sekiguchi, Naohiro
AU  - Sekiguchi N
FAU - Yokota, Yukiko
AU  - Yokota Y
FAU - Kaneko, Akihiro
AU  - Kaneko A
FAU - Watanabe, Takashi
AU  - Watanabe T
FAU - Maeshima, Akiko Miyagi
AU  - Maeshima AM
FAU - Matsuno, Yoshihiro
AU  - Matsuno Y
FAU - Harada, Mine
AU  - Harada M
FAU - Tobinai, Kensei
AU  - Tobinai K
FAU - Kobayashi, Yukio
AU  - Kobayashi Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061020
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Eye Neoplasms/diagnosis/*genetics/pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Lymphoma, B-Cell, Marginal Zone/diagnosis/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Trisomy/genetics
PMC - PMC1630703
EDAT- 2006/10/21 09:00
MHDA- 2007/01/04 09:00
PMCR- 2006/10/20
CRDT- 2006/10/21 09:00
PHST- 2006/07/27 00:00 [received]
PHST- 2006/10/20 00:00 [accepted]
PHST- 2006/10/21 09:00 [pubmed]
PHST- 2007/01/04 09:00 [medline]
PHST- 2006/10/21 09:00 [entrez]
PHST- 2006/10/20 00:00 [pmc-release]
AID - 1471-2407-6-249 [pii]
AID - 10.1186/1471-2407-6-249 [doi]
PST - epublish
SO  - BMC Cancer. 2006 Oct 20;6:249. doi: 10.1186/1471-2407-6-249.