PMID- 1705269
OWN - NLM
STAT- MEDLINE
DCOM- 19910402
LR  - 20151119
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 302
IP  - 2
DP  - 1990 Dec 8
TI  - Substance P- and opioid-immunoreactive structures in olfactory centers of the 
      cat: adult pattern and postnatal development.
PG  - 349-69
AB  - Substance P (SP)-ir and opioid-ir structures were studied in the cat main 
      olfactory bulb (MOB), accessory olfactory bulb (AOB), and olfactory peduncle. In 
      the MOB, the opioid-ir and the majority of the SP-ir neurons belong to the 
      granule cell type. SP-ir granule cells reside in the deeper granule cell layer, 
      whereas opioid-ir granule cells reside in the superficial granule cell layer, 
      internal plexiform, and mitral cell layer. Many granule cells are observed in the 
      external plexiform and glomerular layer. Other granule cells were found in the 
      bulbar/peduncular white matter, the taenia tecta, and the genu of the corpus 
      callosum. A new substance P-ir cell type was identified in the glomerular layer. 
      This cell type was also identified by using the technique of intracellular 
      injection of Lucifer Yellow. The cell type corresponds neither to the external 
      tufted type nor to the short axon cell types described so far. The AOB resembles 
      the MOB with respect to large numbers of SP-ir and opioid-ir granule cells. In 
      addition, a few opioid-ir neurons, probably superficial mitral cells, were found 
      in the glomerular layer. The AOB is surrounded by islands of immunoreactive 
      granule cells, which connect to the granule cell layer by extremely long 
      processes. Opioid-ir and SP-ir beaded axons pass through the olfactory peduncle 
      terminating on granule cells, and ascend as far as the glomerular layer. All 
      subdivisions of the anterior olfactory nucleus (AON) contain immunoreactive 
      terminal fields. Afferent fibers and terminal plexuses derive from a population 
      of immunoreactive neurons located predominantly in the region of the 
      septo-olfactory junction. They have large somata. Their axons form recurrent 
      collaterals, some of which run rostrally in the peduncular white matter. Others 
      ascend caudally towards the septal region. The fibers seem to remain 
      ipsilaterally, since the olfactory limb of the anterior commissure and the 
      commissure proper are devoid of SP-ir and opioid-ir fibers. During development SP 
      and opioid immunoreactivity were found only in differentiated granule cells. The 
      peptides were not detectable in migrating or immature granule cells, as 
      identified in Golgi-impregnated material. The granule cell population largely 
      develops during postnatal life. The number of opioid-ir granule cells increases 
      slowly and continuously, reaching the adult level not before the sixth postnatal 
      month. Strikingly, SP-ir granule cell number increases fast and reaches a 
      transient peak during the second month. Thereafter it declines (40% decrease) to 
      the adult density, which is similar to that of opioid-ir granule cells.
FAU - Wahle, P
AU  - Wahle P
AD  - Max-Planck-Institut fur Biophysikalische Chemie, Gottingen, Federal Republic of 
      Germany.
FAU - Sanides-Kohlrausch, C
AU  - Sanides-Kohlrausch C
FAU - Meyer, G
AU  - Meyer G
FAU - Lubke, J
AU  - Lubke J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Endorphins)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Isoquinolines)
RN  - 33507-63-0 (Substance P)
RN  - 9654F8OVKE (lucifer yellow)
SB  - IM
MH  - Afferent Pathways/chemistry
MH  - Animals
MH  - Cats/*anatomy & histology/growth & development/metabolism
MH  - Endorphins/*analysis
MH  - Fluorescent Dyes
MH  - Immunoenzyme Techniques
MH  - Interneurons/chemistry
MH  - Isoquinolines
MH  - Olfactory Bulb/*chemistry/growth & development
MH  - Substance P/*analysis
EDAT- 1990/12/08 00:00
MHDA- 1990/12/08 00:01
CRDT- 1990/12/08 00:00
PHST- 1990/12/08 00:00 [pubmed]
PHST- 1990/12/08 00:01 [medline]
PHST- 1990/12/08 00:00 [entrez]
AID - 10.1002/cne.903020212 [doi]
PST - ppublish
SO  - J Comp Neurol. 1990 Dec 8;302(2):349-69. doi: 10.1002/cne.903020212.