PMID- 17052731
OWN - NLM
STAT- MEDLINE
DCOM- 20070103
LR  - 20131121
IS  - 0022-4804 (Print)
IS  - 0022-4804 (Linking)
VI  - 136
IP  - 2
DP  - 2006 Dec
TI  - The post-operative level of serum monocyte chemoattractant protein-1 and its 
      correlation with the severity of surgical stress.
PG  - 314-9
AB  - BACKGROUND: Several basic studies have demonstrated that monocyte chemoattractant 
      protein-1 (MCP-1) influences type 2 cytokine production and cell-mediated 
      immunity. However, there have been few reports on the changes in serum MCP-1 
      levels in patients undergoing major thoracoabdominal surgery. In this study, we 
      examined the kinetics of serum MCP-1 post-operatively and clarified its 
      significance regarding the extent of surgical stress. MATERIALS AND METHODS: 
      Seventeen patients who underwent surgical operations were included in this study. 
      All of them were fed by total parenteral nutrition to deliver the same amount of 
      calories and nitrogen. Of the severely stressed group, nine patients underwent 
      esophagectomy with thoracotomy. Of the group of moderately stressed group, eight 
      patients underwent gastric or colorectal surgery. Serum MCP-1 and interleukin-6 
      (IL-6) were measured after operation. Cell-mediated immunity was measured by 
      concanavalin A- or phytohemagglutinin-stimulated lymphocyte proliferation on the 
      seventh post-operative day. RESULTS: Serum MCP-1 and IL-6 were increased 
      immediately after surgery in both groups. The level of MCP-1 was significantly 
      higher in the group of severely stressed patients than in the moderately stressed 
      group. Concanavalin A or phytohemagglutinin-stimulated lymphocyte proliferation 
      was significantly lower in the severely stressed group than in the moderately 
      stressed group. CONCLUSIONS: These results indicate that serum MCP-1 levels are 
      directly correlated, and cell-mediated immunity inversely correlated, with the 
      severity of surgical stress.
FAU - Shibasaki, Hidehito
AU  - Shibasaki H
AD  - Department of General Surgery, Chiba University Graduate School of Medicine, 
      Chiba, Japan.
FAU - Furukawa, Katsunori
AU  - Furukawa K
FAU - Yamamori, Hideo
AU  - Yamamori H
FAU - Kimura, Fumio
AU  - Kimura F
FAU - Tashiro, Tsuguhiko
AU  - Tashiro T
FAU - Miyazaki, Masaru
AU  - Miyazaki M
LA  - eng
PT  - Journal Article
DEP - 20061017
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Phytohemagglutinins)
RN  - 11028-71-0 (Concanavalin A)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Aged
MH  - Cell Division/drug effects/immunology
MH  - Chemokine CCL2/blood/*immunology
MH  - Concanavalin A/pharmacology
MH  - Energy Intake
MH  - *Esophagectomy
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Lymphocytes/immunology
MH  - Male
MH  - Middle Aged
MH  - Nitrogen/metabolism
MH  - Phytohemagglutinins/pharmacology
MH  - Postoperative Complications/blood/*immunology
MH  - *Severity of Illness Index
MH  - Stress, Physiological/blood/etiology/*immunology
EDAT- 2006/10/21 09:00
MHDA- 2007/01/04 09:00
CRDT- 2006/10/21 09:00
PHST- 2006/04/29 00:00 [received]
PHST- 2006/07/21 00:00 [revised]
PHST- 2006/07/24 00:00 [accepted]
PHST- 2006/10/21 09:00 [pubmed]
PHST- 2007/01/04 09:00 [medline]
PHST- 2006/10/21 09:00 [entrez]
AID - S0022-4804(06)00408-2 [pii]
AID - 10.1016/j.jss.2006.07.043 [doi]
PST - ppublish
SO  - J Surg Res. 2006 Dec;136(2):314-9. doi: 10.1016/j.jss.2006.07.043. Epub 2006 Oct 
      17.