PMID- 17054582
OWN - NLM
STAT- MEDLINE
DCOM- 20070105
LR  - 20061023
IS  - 1443-9611 (Print)
IS  - 1443-9573 (Linking)
VI  - 7
IP  - 4
DP  - 2006
TI  - Effect of a prebiotic-enriched phytocompound in improving ovalbumin 
      allergenicity.
PG  - 206-10
AB  - OBJECTIVE: The aim of the present study was to test a prebiotic-phytotherapic 
      compound in an experimental model of oral allergenicity. METHODS: 
      Antigen-specific immunoglobulin E (IgE) elevated mice were prepared by injecting 
      them intraperitoneally with 10 microg of ovalbumin. Subsequently, the mice were 
      exposed to ovalbumin solution intranasally and blood samples were obtained on 
      weekly intervals for 4 weeks to measure serum-ovalbumin-specific IgE and total 
      immunoglobulin G. Mice with high titers of ovalbumin-IgE were intragastrically 
      administered with 0.3 mL of phosphate buffered solution containing either 20 mg 
      of ovalbumin, the same solution with 5 mL of milk, or 20 mg milk added to 
      prebiotic-phytocompound. RESULTS: Ovalbumin administration caused a significant 
      increase of plasma ovalbumin concentration in sensitized mice while 
      prebiotic-phytocompound-supplemented mice showed a significantly reduced peak 
      value (P < 0.05). Prebiotic-phytocompound added to milk exerted a significant 
      effect in lowering the ovalbumin-IgE level and the total immunoglobulin G level 
      as compared to control plain milk (P < 0.01). CONCLUSION: This study provides a 
      rationale basis for a feasible non-pharmacological therapeutic strategy in food 
      allergen hypersensitivity syndromes.
FAU - Metugriachuk, Yussef
AU  - Metugriachuk Y
AD  - Tsuchiya Medical Corporation Hospital, University of Milan, Italy.
FAU - Tsuchiya, Juichiro
AU  - Tsuchiya J
FAU - Marotta, Francesco
AU  - Marotta F
FAU - Kawakita, Sam
AU  - Kawakita S
FAU - Okura, Ruichi
AU  - Okura R
FAU - Kuroi, Olivia
AU  - Kuroi O
FAU - Minelli, Emilio
AU  - Minelli E
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Chin J Dig Dis
JT  - Chinese journal of digestive diseases
JID - 101088612
RN  - 0 (Immunoglobulin G)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Food Hypersensitivity/*drug therapy/immunology
MH  - Immunoglobulin G/blood
MH  - *Lactobacillus
MH  - Male
MH  - Mice
MH  - Milk
MH  - Ovalbumin/*adverse effects/blood/immunology
MH  - Phytotherapy
MH  - Probiotics/*administration & dosage
EDAT- 2006/10/24 09:00
MHDA- 2007/01/06 09:00
CRDT- 2006/10/24 09:00
PHST- 2006/10/24 09:00 [pubmed]
PHST- 2007/01/06 09:00 [medline]
PHST- 2006/10/24 09:00 [entrez]
AID - CDD267 [pii]
AID - 10.1111/j.1443-9573.2006.00267.x [doi]
PST - ppublish
SO  - Chin J Dig Dis. 2006;7(4):206-10. doi: 10.1111/j.1443-9573.2006.00267.x.