PMID- 17055211
OWN - NLM
STAT- MEDLINE
DCOM- 20070226
LR  - 20191210
IS  - 0753-3322 (Print)
IS  - 0753-3322 (Linking)
VI  - 60
IP  - 10
DP  - 2006 Dec
TI  - Genetic basis of rheumatoid arthritis.
PG  - 656-62
AB  - Rheumatoid arthritis (RA) is a clinically heterogeneous condition with a complex 
      aetiology in which environmental and genetic factors are implicated. The 
      contribution of human leukocyte antigen (HLA) genes, particularly the HLA-DRB1 
      gene, to RA genetic predisposition was the first described, and remains as the 
      best characterised single genetic risk factor contributing to RA. However, it has 
      been estimated that only 30% of the genetic contribution to RA can be attributed 
      to HLA genes and it is suggested that other non-HLA genes may play a relevant 
      role in RA susceptibility. Linkage studies and association studies are the two 
      main strategies used in the investigation of genetic factors contributing to 
      complex genetic traits. In this work we review the progress made in the field of 
      RA genetics, focusing mainly on the contribution of candidate gene association 
      studies to the dissection of RA genetic risk factors.
FAU - Orozco, G
AU  - Orozco G
AD  - Instituto de Parasitologia y Biomedicina Lopez-Neyra, Consejo Superior de 
      Investigaciones Cientificas (CSIC), Parque Tecnologico de Ciencias de la Salud, 
      Avenida del Conocimiento s/n 18100 Armilla, Granada, Spain.
FAU - Rueda, B
AU  - Rueda B
FAU - Martin, J
AU  - Martin J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20061016
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Chemotactic Factors)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (macrophage migration enhancement factor)
RN  - EC 3.- (Hydrolases)
RN  - EC 3.1.3.48 (PTPN22 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 22)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
RN  - EC 3.5.3.15 (PADI4 protein, human)
RN  - EC 3.5.3.15 (Protein-Arginine Deiminase Type 4)
RN  - EC 3.5.3.15 (Protein-Arginine Deiminases)
SB  - IM
MH  - Antigens, CD/genetics
MH  - Antigens, Differentiation/genetics
MH  - Arthritis, Rheumatoid/*genetics/pathology
MH  - CTLA-4 Antigen
MH  - Chemotactic Factors/genetics
MH  - Genetic Heterogeneity
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Hydrolases/genetics
MH  - Macrophages
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 22
MH  - Protein Tyrosine Phosphatases/genetics
MH  - Protein-Arginine Deiminase Type 4
MH  - Protein-Arginine Deiminases
RF  - 112
EDAT- 2006/10/24 09:00
MHDA- 2007/02/27 09:00
CRDT- 2006/10/24 09:00
PHST- 2006/08/01 00:00 [received]
PHST- 2006/09/21 00:00 [accepted]
PHST- 2006/10/24 09:00 [pubmed]
PHST- 2007/02/27 09:00 [medline]
PHST- 2006/10/24 09:00 [entrez]
AID - S0753-3322(06)00288-5 [pii]
AID - 10.1016/j.biopha.2006.09.003 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2006 Dec;60(10):656-62. doi: 10.1016/j.biopha.2006.09.003. 
      Epub 2006 Oct 16.