PMID- 17055560
OWN - NLM
STAT- MEDLINE
DCOM- 20070117
LR  - 20220309
IS  - 0091-3022 (Print)
IS  - 1095-6808 (Electronic)
IS  - 0091-3022 (Linking)
VI  - 27
IP  - 4
DP  - 2006 Dec
TI  - Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity 
      of steroid hormone-growth factor interactions in the adult CNS.
PG  - 415-35
AB  - In the CNS, there are widespread and diverse interactions between growth factors 
      and estrogen. Here we examine the interactions of estrogen and brain-derived 
      neurotrophic factor (BDNF), two molecules that have historically been studied 
      separately, despite the fact that they seem to share common targets, effects, and 
      mechanisms of action. The demonstration of an estrogen-sensitive response element 
      on the BDNF gene provided an impetus to explore a direct relationship between 
      estrogen and BDNF, and predicted that the effects of estrogen, at least in part, 
      might be due to the induction of BDNF. This hypothesis is discussed with respect 
      to the hippocampus, where substantial evidence has accumulated in favor of it, 
      but alternate hypotheses are also raised. It is suggested that some of the 
      interactions between estrogen and BDNF, as well as the controversies and 
      implications associated with their respective actions, may be best appreciated in 
      light of the ability of BDNF to induce neuropeptide Y (NPY) synthesis in 
      hippocampal neurons. Taken together, this tri-molecular cascade, 
      estrogen-BDNF-NPY, may be important in understanding the hormonal regulation of 
      hippocampal function. It may also be relevant to other regions of the CNS where 
      estrogen is known to exert profound effects, such as amygdala and hypothalamus; 
      and may provide greater insight into neurological disorders and psychiatric 
      illness, including Alzheimer's disease, depression and epilepsy.
FAU - Scharfman, Helen E
AU  - Scharfman HE
AD  - Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, 
      West Haverstraw, NY 10093-1195, USA. scharfmanh@helenhayeshosp.org
FAU - MacLusky, Neil J
AU  - MacLusky NJ
LA  - eng
GR  - R01 NS037562/NS/NINDS NIH HHS/United States
GR  - R56 NS037562/NS/NINDS NIH HHS/United States
GR  - NS 37562/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20061020
PL  - United States
TA  - Front Neuroendocrinol
JT  - Frontiers in neuroendocrinology
JID - 7513292
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Estrogens)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Steroids)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Central Nervous System/*physiology
MH  - Estrogens/*physiology
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*physiology
MH  - Mental Disorders/physiopathology
MH  - Nervous System Diseases/physiopathology
MH  - Neuropeptide Y/physiology
MH  - Steroids/*physiology
PMC - PMC1778460
MID - NIHMS14582
EDAT- 2006/10/24 09:00
MHDA- 2007/01/18 09:00
PMCR- 2008/01/30
CRDT- 2006/10/24 09:00
PHST- 2006/02/27 00:00 [received]
PHST- 2006/08/12 00:00 [revised]
PHST- 2006/09/01 00:00 [accepted]
PHST- 2006/10/24 09:00 [pubmed]
PHST- 2007/01/18 09:00 [medline]
PHST- 2006/10/24 09:00 [entrez]
PHST- 2008/01/30 00:00 [pmc-release]
AID - S0091-3022(06)00376-1 [pii]
AID - 10.1016/j.yfrne.2006.09.004 [doi]
PST - ppublish
SO  - Front Neuroendocrinol. 2006 Dec;27(4):415-35. doi: 10.1016/j.yfrne.2006.09.004. 
      Epub 2006 Oct 20.