PMID- 17056512
OWN - NLM
STAT- MEDLINE
DCOM- 20061213
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 177
IP  - 9
DP  - 2006 Nov 1
TI  - Aberrant phenotype and function of myeloid dendritic cells in systemic lupus 
      erythematosus.
PG  - 5878-89
AB  - Systemic lupus erythematosus (SLE) is characterized by a systemic autoimmune 
      response with profound and diverse T cell changes. Dendritic cells (DCs) are 
      important orchestrators of immune responses and have an important role in the 
      regulation of T cell function. The objective of this study was to determine 
      whether myeloid DCs from individuals with SLE display abnormalities in phenotype 
      and promote abnormal T cell function. Monocyte-derived DCs and freshly isolated 
      peripheral blood myeloid DCs from lupus patients displayed an abnormal phenotype 
      characterized by accelerated differentiation, maturation, and secretion of 
      proinflammatory cytokines. These abnormalities were characterized by higher 
      expression of the DC differentiation marker CD1a, the maturation markers CD86, 
      CD80, and HLA-DR, and the proinflammatory cytokine IL-8. In addition, SLE 
      patients displayed selective down-regulation of the maturation marker CD83 and 
      had abnormal responses to maturation stimuli. These abnormalities have functional 
      relevance, as SLE DCs were able to significantly increase proliferation and 
      activation of allogeneic T cells when compared with control DCs. We conclude that 
      myeloid DCs from SLE patients display significant changes in phenotype which 
      promote aberrant T cell function and could contribute to the pathogenesis of SLE 
      and organ damage.
FAU - Ding, Dacheng
AU  - Ding D
AD  - Department of Internal Medicine, Division of Rheumatology, University of 
      Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA.
FAU - Mehta, Hemal
AU  - Mehta H
FAU - McCune, W Joseph
AU  - McCune WJ
FAU - Kaplan, Mariana J
AU  - Kaplan MJ
LA  - eng
GR  - AR 048235/AR/NIAMS NIH HHS/United States
GR  - AR 050554/AR/NIAMS NIH HHS/United States
GR  - P30 AR 48310/AR/NIAMS NIH HHS/United States
GR  - P30 CA 46592/CA/NCI NIH HHS/United States
GR  - T32 AR 07080/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, CD)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adult
MH  - Antigens, CD/analysis
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Dendritic Cells/chemistry/*immunology/*pathology
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Interleukin-8/metabolism
MH  - Lupus Erythematosus, Systemic/*immunology/*pathology
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Monocytes/immunology/pathology
MH  - Myeloid Cells/chemistry/*immunology/*pathology
MH  - Phenotype
MH  - T-Lymphocytes/immunology
MH  - Up-Regulation
EDAT- 2006/10/24 09:00
MHDA- 2006/12/14 09:00
CRDT- 2006/10/24 09:00
PHST- 2006/10/24 09:00 [pubmed]
PHST- 2006/12/14 09:00 [medline]
PHST- 2006/10/24 09:00 [entrez]
AID - 177/9/5878 [pii]
AID - 10.4049/jimmunol.177.9.5878 [doi]
PST - ppublish
SO  - J Immunol. 2006 Nov 1;177(9):5878-89. doi: 10.4049/jimmunol.177.9.5878.