PMID- 17056542
OWN - NLM
STAT- MEDLINE
DCOM- 20061213
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 177
IP  - 9
DP  - 2006 Nov 1
TI  - CC-chemokine ligand 16 induces a novel maturation program in human immature 
      monocyte-derived dendritic cells.
PG  - 6143-51
AB  - Dendritic cells (DCs) are indispensable for initiation of primary T cell 
      responses and a host's defense against infection. Many proinflammatory stimuli 
      induce DCs to mature (mDCs), but little is known about the ability of chemokines 
      to modulate their maturation. In the present study, we report that CCL16 is a 
      potent maturation factor for monocyte-derived DCs (MoDCs) through differential 
      use of its four receptors and an indirect regulator of Th cell differentiation. 
      MoDCs induced to mature by CCL16 are characterized by increased expression of 
      CD80 and CD86, MHC class II molecules, and ex novo expression of CD83 and CCR7. 
      They produce many chemokines to attract monocytes and T cells and are also strong 
      stimulators in activating allogeneic T cells to skew toward Th1 differentiation. 
      Interestingly, they are still able to take up Ag and express chemokine receptors 
      usually bound by inflammatory ligands and can be induced to migrate to different 
      sites where they capture Ags. Our findings indicate that induction of MoDC 
      maturation is an important property of CCL16 and suggest that chemokines may not 
      only organize the migration of MoDCs, but also directly regulate their ability to 
      prime T cell responses.
FAU - Cappello, Paola
AU  - Cappello P
AD  - Center for Experimental Research and Medical Studies, San Giovanni Battista 
      Hospital, Turin, Italy.
FAU - Fraone, Tiziana
AU  - Fraone T
FAU - Barberis, Laura
AU  - Barberis L
FAU - Costa, Carlotta
AU  - Costa C
FAU - Hirsch, Emilio
AU  - Hirsch E
FAU - Elia, Angela R
AU  - Elia AR
FAU - Caorsi, Cristiana
AU  - Caorsi C
FAU - Musso, Tiziana
AU  - Musso T
FAU - Novelli, Francesco
AU  - Novelli F
FAU - Giovarelli, Mirella
AU  - Giovarelli M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, CD)
RN  - 0 (CCL16 protein, human)
RN  - 0 (CCR7 protein, human)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CC)
RN  - 0 (Cytokines)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Ligands)
RN  - 0 (Receptors, CCR7)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Antigens, CD/analysis
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Chemokines/metabolism
MH  - Chemokines, CC/*pharmacology/physiology
MH  - Cytokines/metabolism
MH  - Dendritic Cells/drug effects/*immunology
MH  - Histocompatibility Antigens Class II/analysis
MH  - Humans
MH  - Ligands
MH  - Lymphocyte Activation
MH  - Monocytes/drug effects/*immunology
MH  - Receptors, CCR7
MH  - Receptors, Chemokine/analysis
MH  - T-Lymphocytes/immunology
EDAT- 2006/10/24 09:00
MHDA- 2006/12/14 09:00
CRDT- 2006/10/24 09:00
PHST- 2006/10/24 09:00 [pubmed]
PHST- 2006/12/14 09:00 [medline]
PHST- 2006/10/24 09:00 [entrez]
AID - 177/9/6143 [pii]
AID - 10.4049/jimmunol.177.9.6143 [doi]
PST - ppublish
SO  - J Immunol. 2006 Nov 1;177(9):6143-51. doi: 10.4049/jimmunol.177.9.6143.