PMID- 17056627
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20181113
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Print)
IS  - 0022-3050 (Linking)
VI  - 78
IP  - 4
DP  - 2007 Apr
TI  - Epidemiology of myasthenia gravis with anti-muscle specific kinase antibodies in 
      The Netherlands.
PG  - 417-8
AB  - The epidemiology of myasthenia gravis subtypes and the frequency of antibodies to 
      muscle-specific kinase (MuSK) was studied in patients with generalised myasthenia 
      gravis without anti-acetylcholine receptor antibodies who had an onset of 
      symptoms between 1990 and 2004 in a well-defined region in The Netherlands. The 
      nationwide prevalence and incidence of myasthenia gravis with anti-MuSK 
      antibodies were also studied. MuSK antibodies were found in 22% of patients with 
      generalised myasthenia gravis without anti-acetylcholine receptor antibodies. 
      Nationwide, 35 patients with MuSK myasthenia gravis were identified, yielding a 
      prevalence of 1.9 per million (95% confidence interval (CI) 1.22 to 2.59) and an 
      annual incidence 0.10 per million person-years (95% CI 0.06 to 0.14).
FAU - Niks, Erik H
AU  - Niks EH
AD  - Department of Neurology, J3-R 166, Leiden University Medical Centre, PO Box 9600, 
      2300 RC Leiden, The Netherlands. ehniks@lumc.nl
FAU - Kuks, Jan B M
AU  - Kuks JB
FAU - Verschuuren, Jan J G M
AU  - Verschuuren JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061020
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Antibodies)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/*epidemiology/*immunology
MH  - Netherlands/epidemiology
MH  - Prevalence
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
PMC - PMC2077782
COIS- Competing interests: None.
EDAT- 2006/10/24 09:00
MHDA- 2007/03/30 09:00
PMCR- 2010/04/01
CRDT- 2006/10/24 09:00
PHST- 2006/10/24 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2006/10/24 09:00 [entrez]
PHST- 2010/04/01 00:00 [pmc-release]
AID - jnnp.2006.102517 [pii]
AID - jn102517 [pii]
AID - 10.1136/jnnp.2006.102517 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):417-8. doi: 
      10.1136/jnnp.2006.102517. Epub 2006 Oct 20.