PMID- 17060851
OWN - NLM
STAT- MEDLINE
DCOM- 20061130
LR  - 20061024
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 82
IP  - 8
DP  - 2006 Oct 27
TI  - Matching of the minor histocompatibility antigen HLA-A1/H-Y may improve prognosis 
      in corneal transplantation.
PG  - 1037-41
AB  - BACKGROUND: Minor histocompatibility (H) antigens are peptides of allelic 
      intracellular proteins that play an important role in human leukocyte antigen 
      (HLA) matched transplantations. In an animal model of keratoplasty, minor H 
      antigens have even been reported to exceed the immunogenicity of major H antigens 
      (MHC). This investigation is to assess any benefit of matching the broadly 
      expressed gender (H-Y) and HA-3 antigens in HLA-A1 donor positive human 
      keratoplasty. METHODS: A total of 229 HLA-A1 donor positive keratoplasties were 
      analyzed. A Cox proportional hazards model and Kaplan-Meier analysis were applied 
      to estimate the effect of H-Y or HA-3 mismatches on rejection-free graft 
      survival. RESULTS: Eighty-one cases were mismatched for H-Y (male donor to female 
      recipient). A mean follow up of two years showed graft survival as high as 88% in 
      the H-Y compatible group compared to only 77% in the H-Y mismatched group (P = 
      0.02). Eight out of 62 cases were mismatched for HA-3. No statistically 
      significant influence of HA-3 matching on rejection-free graft survival was 
      observed (85% vs. 73%, P=0.52). CONCLUSION: HLA-A1/H-Y matching and matching for 
      other broadly expressed minor H antigens may further improve prognosis in 
      keratoplasty.
FAU - Bohringer, Daniel
AU  - Bohringer D
AD  - Eye Hospital and LIONS Cornea Bank Regio/Baden-Wurttemberg, University Hospital 
      Freiburg, Germany. daniel.boehringer@uniklinik-freiburg.de
FAU - Spierings, Eric
AU  - Spierings E
FAU - Enczmann, Jurgen
AU  - Enczmann J
FAU - Bohringer, Stefan
AU  - Bohringer S
FAU - Sundmacher, Rainer
AU  - Sundmacher R
FAU - Goulmy, Els
AU  - Goulmy E
FAU - Reinhard, Thomas
AU  - Reinhard T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (H-Y Antigen)
RN  - 0 (HLA-A1 Antigen)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Corneal Diseases/*genetics/*immunology
MH  - Corneal Transplantation/*methods
MH  - Disease-Free Survival
MH  - Female
MH  - Graft Survival
MH  - H-Y Antigen/*genetics
MH  - HLA-A1 Antigen/*genetics
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Treatment Outcome
EDAT- 2006/10/25 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/10/25 09:00
PHST- 2006/10/25 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/10/25 09:00 [entrez]
AID - 00007890-200610270-00006 [pii]
AID - 10.1097/01.tp.0000235908.54766.44 [doi]
PST - ppublish
SO  - Transplantation. 2006 Oct 27;82(8):1037-41. doi: 
      10.1097/01.tp.0000235908.54766.44.