PMID- 17060859
OWN - NLM
STAT- MEDLINE
DCOM- 20061130
LR  - 20061024
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 82
IP  - 8
DP  - 2006 Oct 27
TI  - Association of human leukocyte antigen haplotypes with posttransplant 
      lymphoproliferative disease after solid organ transplantation.
PG  - 1093-100
AB  - BACKGROUND: Posttransplant lymphoproliferative disease (PTLD) after solid organ 
      transplantation (SOT) is commonly characterized by Epstein-Barr virus 
      (EBV)-driven proliferation of recipient B cells due to impaired immune 
      surveillance in the context of immunosuppression. Because EBV-specific T-cell 
      responses are focused on the level of EBV antigen and epitope choice depending on 
      the individual human leukocyte antigen (HLA) alleles, we hypothesized that 
      certain HLA alleles or a distinct HLA haplotype may influence the risk of 
      development of PTLD after SOT. METHODS: A multicenter case-control study was 
      performed comparing a group of 155 recipients after SOT with development of PTLD 
      with a group of 1996 recipients after SOT without development of PTLD. Alleles, 
      genotypes, and three locus haplotypes were compared of SOT recipients with and 
      without PTLD. RESULTS: The bivariate analysis showed that carrying HLA-A03 was 
      negatively associated (odds ratio [OR] 0.61, confidence interval [CI] 0.40-0.92, 
      P < 0.02) whereas carrying of HLA-B18 (OR 1.79, CI 1.18-2.73, P < 0.006) and 
      HLA-B21 (OR 2.08, CI 1.14-3.77, P < 0.02) were positively associated with PTLD 
      after SOT. HLA-DR analysis demonstrated a significant negative association 
      between the expression of HLA-DR7 (OR 0.46, CI 0.28-0.78, P < 0.004) and PTLD. 
      Three locus haplotype analysis underlined the relevance of a dominant protective 
      effect of HLA-DR7 expression concerning the risk of PTLD development. 
      CONCLUSIONS: Our data suggest an influence of HLA variants on the risk of the 
      development of PTLD. We hypothesize that HLA genes or non-HLA genes within the 
      HLA loci confer a risk modification for the individual patient.
FAU - Subklewe, Marion
AU  - Subklewe M
AD  - Charite-Universitaetsmedizin Berlin, Campus Virchow Klinikum, Med. Klinik m. S. 
      Haematologie/Onkologie, Berlin, Germany. marion.subklewe@charite.de
FAU - Marquis, Rene
AU  - Marquis R
FAU - Choquet, Sylvain
AU  - Choquet S
FAU - Leblond, Veronique
AU  - Leblond V
FAU - Garnier, Jeanne-Luce
AU  - Garnier JL
FAU - Hetzer, Roland
AU  - Hetzer R
FAU - Swinnen, Lode J
AU  - Swinnen LJ
FAU - Oertel, Stephan
AU  - Oertel S
FAU - Papp-Vary, Matthias
AU  - Papp-Vary M
FAU - Gonzalez-Barca, Eva
AU  - Gonzalez-Barca E
FAU - Hepkema, Bouke G
AU  - Hepkema BG
FAU - Schoenemann, Constanze
AU  - Schoenemann C
FAU - May, Juergen
AU  - May J
FAU - Pezzutto, Antonio
AU  - Pezzutto A
FAU - Riess, Hanno
AU  - Riess H
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Antigen Presentation
MH  - B-Lymphocytes/immunology
MH  - Case-Control Studies
MH  - Epitopes/chemistry
MH  - Female
MH  - HLA Antigens/*chemistry/immunology
MH  - Haplotypes
MH  - Herpesvirus 4, Human/metabolism
MH  - Humans
MH  - Lymphoproliferative Disorders/*immunology
MH  - Male
MH  - Middle Aged
MH  - Organ Transplantation/*methods
MH  - Postoperative Complications
MH  - Retrospective Studies
MH  - Risk
EDAT- 2006/10/25 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/10/25 09:00
PHST- 2006/10/25 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/10/25 09:00 [entrez]
AID - 00007890-200610270-00014 [pii]
AID - 10.1097/01.tp.0000235889.05171.12 [doi]
PST - ppublish
SO  - Transplantation. 2006 Oct 27;82(8):1093-100. doi: 
      10.1097/01.tp.0000235889.05171.12.