PMID- 17061018
OWN - NLM
STAT- MEDLINE
DCOM- 20070529
LR  - 20181113
IS  - 1436-6207 (Print)
IS  - 1436-6207 (Linking)
VI  - 45
IP  - 7
DP  - 2006 Oct
TI  - Medium-term methionine supplementation increases plasma homocysteine but not ADMA 
      and improves blood pressure control in rats fed a diet rich in protein and 
      adequate in folate and choline.
PG  - 383-90
AB  - BACKGROUND: Hyperhomocysteinemia (HHcy) is associated with cardiovascular risk, 
      possibly because it increases asymmetric dimethyl-arginine (ADMA), but the 
      general association remains unclear and may vary with nutritional and 
      physiological conditions. AIM OF THE STUDY: We aimed to monitor the effect of 
      methionine supplementation, and subsequent HHcy, on plasma ADMA and hemodynamics 
      in the context of a diet rich in protein and adequate in folic acid and choline. 
      METHODS: For 6 weeks, rats were fed a 29% protein diet supplemented (M) or not 
      (C) with 8 g/kg L: -methionine. Blood pressure and plasma amino acids, including 
      homocysteine and ADMA, were measured throughout the experiment and additional 
      parameters, including in vivo hemodynamic response to acetylcholine, were 
      measured at week 5-6. RESULTS: As compared to the C diet, the M diet induced a 
      marked HHcy during the first 3 weeks, which lessened at week 5. In contrast, 
      plasma ADMA stayed similar in the C and M diet. Paradoxically, M rats had lower 
      mean and diastolic blood pressure values over the experiment, together with a 
      lower left ventricular mass at week 6, when compared with C rats. No difference 
      was observed between groups regarding vascular reactivity and plasma NOx at week 
      6. CONCLUSIONS: In a context of a diet rich in protein and adequate in methyl 
      donors, rats exhibit a complex adaptation to the medium-term methionine 
      supplementation, with improvement in blood pressure control despite marked HHcy. 
      The lack of increase in plasma ADMA may account for the absence of detrimental 
      effects of HHcy on hemodynamics.
FAU - Mariotti, Francois
AU  - Mariotti F
AD  - UMR INRA-INAPG 914 Physiologie de la, Nutrition et du Comportement Alimentaire, 
      Institut National Agronomique, Paris-Grignon, Paris, France. 
      mariotti@inapg.inra.fr
FAU - Hammiche, Alexia
AU  - Hammiche A
FAU - Blouet, Clemence
AU  - Blouet C
FAU - Dare, Sophie
AU  - Dare S
FAU - Tome, Daniel
AU  - Tome D
FAU - Huneau, Jean Francois
AU  - Huneau JF
LA  - eng
PT  - Journal Article
DEP - 20060901
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Dietary Proteins)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 63CV1GEK3Y (N,N-dimethylarginine)
RN  - 935E97BOY8 (Folic Acid)
RN  - 94ZLA3W45F (Arginine)
RN  - AE28F7PNPL (Methionine)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - *Adaptation, Physiological
MH  - Animals
MH  - Area Under Curve
MH  - Arginine/*analogs & derivatives/blood
MH  - Blood Pressure/*drug effects
MH  - Choline/administration & dosage
MH  - Dietary Proteins/administration & dosage
MH  - Dietary Supplements
MH  - Folic Acid/administration & dosage
MH  - Homocysteine/*blood
MH  - Male
MH  - Methionine/administration & dosage/*pharmacology
MH  - Methylation
MH  - Nitric Oxide/blood
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Time Factors
EDAT- 2006/10/25 09:00
MHDA- 2007/05/30 09:00
CRDT- 2006/10/25 09:00
PHST- 2006/04/01 00:00 [received]
PHST- 2006/06/26 00:00 [accepted]
PHST- 2006/10/25 09:00 [pubmed]
PHST- 2007/05/30 09:00 [medline]
PHST- 2006/10/25 09:00 [entrez]
AID - 10.1007/s00394-006-0611-1 [doi]
PST - ppublish
SO  - Eur J Nutr. 2006 Oct;45(7):383-90. doi: 10.1007/s00394-006-0611-1. Epub 2006 Sep 
      1.