PMID- 17062581
OWN - NLM
STAT- MEDLINE
DCOM- 20070504
LR  - 20070219
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 22
IP  - 3
DP  - 2007 Mar
TI  - Meiotic segregation in spermatozoa of a 45,XY,-14,der(18)t(14;18)(q11;p11.3) 
      translocation carrier: a case report.
PG  - 729-32
AB  - A 35-year-old male was found to have a 45,XY,-14,der(18)t(14;18)(q11;p11.3) 
      karyotype during the investigations for a couple with infertility for 8 years. 
      Two sperm samples were obtained and analysed in triple fluorescence in situ 
      hybridization (FISH) with the D18Z1 and LSI IGH/BCL2 probes. The frequency of 
      gametes exhibiting a normal or balanced chromosomal equipment was 87.26 and 
      90.97% in samples 1 and 2, respectively. No statistically significant difference 
      was found between the results of meiotic segregation of both samples. These 
      proportions are close to those observed among Robertsonian translocation 
      carriers. They can probably be explained by the formation of trivalent in cis 
      configuration during meiosis I between the derivative chromosome and the normal 
      chromosomes 14 and 18, as in Robertsonian translocation carriers. These results 
      suggest that the configuration adopted at pachytene strongly determines the 
      segregation mode that will be preferentially followed during anaphase I.
FAU - Perrin, A
AU  - Perrin A
AD  - Laboratoire d'Histologie, Embryologie et Cytogenetique, Faculte de Medecine et 
      des Sciences de la Sante, Universite de Bretagne Occidentale, F-29238 Brest Cedex 
      3, France.
FAU - Douet-Guilbert, N
AU  - Douet-Guilbert N
FAU - Laudier, B
AU  - Laudier B
FAU - Couet, M L
AU  - Couet ML
FAU - Guerif, F
AU  - Guerif F
FAU - Royere, D
AU  - Royere D
FAU - Le Bris, M J
AU  - Le Bris MJ
FAU - De Braekeleer, M
AU  - De Braekeleer M
FAU - Morel, F
AU  - Morel F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061024
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Adult
MH  - *Chromosome Deletion
MH  - Chromosome Segregation/*genetics
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Chromosomes, Human, Pair 18/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*genetics
MH  - Male
MH  - Meiosis/*genetics
MH  - *Translocation, Genetic
EDAT- 2006/10/26 09:00
MHDA- 2007/05/05 09:00
CRDT- 2006/10/26 09:00
PHST- 2006/10/26 09:00 [pubmed]
PHST- 2007/05/05 09:00 [medline]
PHST- 2006/10/26 09:00 [entrez]
AID - del420 [pii]
AID - 10.1093/humrep/del420 [doi]
PST - ppublish
SO  - Hum Reprod. 2007 Mar;22(3):729-32. doi: 10.1093/humrep/del420. Epub 2006 Oct 24.