PMID- 17062984
OWN - NLM
STAT- MEDLINE
DCOM- 20070425
LR  - 20190608
IS  - 0916-8818 (Print)
IS  - 0916-8818 (Linking)
VI  - 53
IP  - 1
DP  - 2007 Feb
TI  - Expression of interleukin-18 receptor mRNA in the mouse endometrium.
PG  - 59-68
AB  - Interleukin-18 (IL-18) is a proinflammatory cytokine involved in chronic 
      inflammation, autoimmune diseases, and a variety of cancers, and is expressed in 
      mouse uteri. Our previous study suggested that IL-18 acts as a paracrine factor, 
      regulating endometrial function. To elucidate the physiological roles of IL-18 in 
      the mouse endometrium, the expression of the IL-18 receptor (IL-18R) alpha 
      subunit was analyzed. IL-18Ralpha mRNA was expressed in several mouse organs in 
      addition to the endometrium. In situ hybridization analysis using a 
      biotin-labeled mouse IL-18Ralpha riboprobe demonstrated that IL-18Ralpha mRNA 
      expression was detected in glandular epithelial cells, stromal cells around 
      uterine glands, and myometrial cells in the mouse uterus, suggesting that these 
      cells are targets for IL-18. The uterine IL-18Ralpha mRNA expression level 
      changed with the estrous cycle. The uterine IL-18Ralpha mRNA levels of estrous 
      mice were higher than those of diestrous mice. In addition, the IL-18Ralpha mRNA 
      levels in uteri at 3 and 14 days after ovariectomy were higher than those at 
      diestrus and decreased following treatment with estradiol-17beta or progesterone. 
      These findings suggest that IL-18Ralpha gene expression is regulated by estrogen 
      and progesterone and that the uterine IL-18 system is involved in the regulation 
      of uterine functions in a paracrine manner.
FAU - Otsuki, Mariko
AU  - Otsuki M
AD  - Department of Biology, Graduate School of Natural Science and Technology, Okayama 
      University, Japan.
FAU - Kusumoto, Kenji
AU  - Kusumoto K
FAU - Murakami, Yousuke
AU  - Murakami Y
FAU - Kanayama, Munetoshi
AU  - Kanayama M
FAU - Takeuchi, Sakae
AU  - Takeuchi S
FAU - Takahashi, Sumio
AU  - Takahashi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061024
PL  - Japan
TA  - J Reprod Dev
JT  - The Journal of reproduction and development
JID - 9438792
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-18 Receptor alpha Subunit)
RN  - 0 (Interleukin-18 Receptor beta Subunit)
RN  - 0 (RNA, Messenger)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Endometrium/*physiology
MH  - Estradiol/pharmacology
MH  - Estrous Cycle/physiology
MH  - Female
MH  - Gene Expression/drug effects/physiology
MH  - In Situ Hybridization
MH  - Interleukin-18/genetics/metabolism
MH  - Interleukin-18 Receptor alpha Subunit/*genetics/*metabolism
MH  - Interleukin-18 Receptor beta Subunit/genetics/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Ovariectomy
MH  - Paracrine Communication/physiology
MH  - Progesterone/pharmacology
MH  - RNA, Messenger/metabolism
MH  - Ribonucleases
EDAT- 2006/10/26 09:00
MHDA- 2007/04/26 09:00
CRDT- 2006/10/26 09:00
PHST- 2006/10/26 09:00 [pubmed]
PHST- 2007/04/26 09:00 [medline]
PHST- 2006/10/26 09:00 [entrez]
AID - JST.JSTAGE/jrd/18036 [pii]
AID - 10.1262/jrd.18036 [doi]
PST - ppublish
SO  - J Reprod Dev. 2007 Feb;53(1):59-68. doi: 10.1262/jrd.18036. Epub 2006 Oct 24.