PMID- 17063465
OWN - NLM
STAT- MEDLINE
DCOM- 20070129
LR  - 20061113
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 46
IP  - 1
DP  - 2007 Jan
TI  - Common fragile site FRA11G and rare fragile site FRA11B at 11q23.3 encompass 
      distinct genomic regions.
PG  - 98-106
AB  - Fragile sites are specific genomic loci that are particularly prone to 
      chromosomal breakage. Based on their incidence in the human population, they are 
      divided into rare fragile sites occurring in less than 5% of all individuals and 
      common fragile sites being a constitutional feature of the genome of probably all 
      individuals. In this study, cloning of unstable DNA sequences, which have been 
      previously genetically tagged with a marker gene, was the basis for defining the 
      genomic localization of the common fragile site FRA11G at 11q23.3. Mapping of the 
      fragile site with six-color fluorescence in situ hybridization (FISH) resulted in 
      the precise genomic localization of FRA11G to a 4.5 Mb region. The chromosomal 
      subband 11q23.3 harbors both the common fragile site FRA11G and the rare fragile 
      site FRA11B. Here, we show that FRA11G maps 0.8 Mb proximal to the genomic region 
      previously defined to be affected by expression of FRA11B; thus, the common and 
      the rare fragile sites at 11q23.3 encompass distinct genomic regions. The region 
      of FRA11G is known to be involved in somatic and germline recurrent aberrations, 
      and it is conceivable that genetic damage resulting from this fragile site might 
      contribute to clinical phenotypes.
CI  - Copyright 2006 Wiley-Liss, Inc.
FAU - Fechter, Anne
AU  - Fechter A
AD  - Division of Tumour Genetics, German Cancer Research Center, 69120 Heidelberg, 
      Germany.
FAU - Buettel, Isabel
AU  - Buettel I
FAU - Kuehnel, Elisabeth
AU  - Kuehnel E
FAU - Savelyeva, Larissa
AU  - Savelyeva L
FAU - Schwab, Manfred
AU  - Schwab M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Breast Neoplasms/genetics
MH  - *Chromosome Fragile Sites
MH  - Chromosome Fragility
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Cloning, Molecular
MH  - Female
MH  - Genes, Reporter
MH  - *Genome, Human
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Models, Genetic
MH  - Mutagenesis, Insertional
MH  - Tumor Cells, Cultured
MH  - Virus Integration
EDAT- 2006/10/26 09:00
MHDA- 2007/01/30 09:00
CRDT- 2006/10/26 09:00
PHST- 2006/10/26 09:00 [pubmed]
PHST- 2007/01/30 09:00 [medline]
PHST- 2006/10/26 09:00 [entrez]
AID - 10.1002/gcc.20389 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2007 Jan;46(1):98-106. doi: 10.1002/gcc.20389.