PMID- 17064798
OWN - NLM
STAT- MEDLINE
DCOM- 20070507
LR  - 20071115
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 117
IP  - 2
DP  - 2007 Apr 25
TI  - Impact of gender on outcomes in chronic systolic heart failure.
PG  - 214-21
AB  - BACKGROUND AND AIM: Understanding the influence of gender in heart failure allows 
      for better treatment. This study described the gender differences in heart 
      failure patients and their response to therapy. METHODS: Consecutive patients 
      (116 men vs. 52 women) from 1997 to 2002 were recruited from a single heart 
      failure unit. Mean follow-up was 40+/-19 months. RESULTS: Mean age was 68+/-12 
      years; left ventricular ejection fraction (LVEF) 27+/-12%. Women had higher mean 
      LVEF, left ventricular end-diastolic diameter, and worse New York Heart 
      Association (NYHA) functional class at baseline compared to men, while age, body 
      mass index, blood pressure, estimated glomerular filtration rate and other 
      co-morbidities did not differ significantly. Fewer women remained on 
      angiotensin-converting-enzyme inhibitors while angiotensin-II-receptor blockers 
      use increased significantly. By the end of the study, both genders exhibited 
      similar magnitude of improvements in LVEF, cardiac dimensions, hemodynamics and 
      mean NYHA functional class. In multivariate analysis, NYHA functional class was 
      the strongest predictor of mortality: patients with NYHA class III/IV at baseline 
      had 2.4-fold increased mortality risk compared to those in NYHA class I/II (95% 
      CI 1.09-5.51, p=0.03). For men, functional class at baseline was the strongest 
      predictor of mortality while for women, it was age at baseline. CONCLUSIONS: In a 
      contemporary tertiary referral heart failure clinic, women were observed to have 
      better LVEF, but worse NYHA functional class than men. Both genders exhibited 
      functional and hemodynamic improvements with only minor differences in their 
      medical therapies. Predictors of mortality differed between the genders.
FAU - Ng, Austin Chin Chwan
AU  - Ng AC
AD  - Heart Failure Unit, Department of Cardiology, Concord RG Hospital, Hospital Road, 
      Concord, NSW 2139 Australia. austin.ng@email.cs.nsw.gov.au
FAU - Wong, Helen Siu Ping
AU  - Wong HS
FAU - Yong, Andy Sze Chiang
AU  - Yong AS
FAU - Sindone, Andrew Paul
AU  - Sindone AP
LA  - eng
PT  - Journal Article
DEP - 20061024
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Comorbidity
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*mortality/therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Sex Distribution
MH  - Survival Analysis
MH  - Systole
MH  - Treatment Outcome
EDAT- 2006/10/27 09:00
MHDA- 2007/05/08 09:00
CRDT- 2006/10/27 09:00
PHST- 2005/12/25 00:00 [received]
PHST- 2006/04/19 00:00 [revised]
PHST- 2006/04/28 00:00 [accepted]
PHST- 2006/10/27 09:00 [pubmed]
PHST- 2007/05/08 09:00 [medline]
PHST- 2006/10/27 09:00 [entrez]
AID - S0167-5273(06)00550-X [pii]
AID - 10.1016/j.ijcard.2006.04.079 [doi]
PST - ppublish
SO  - Int J Cardiol. 2007 Apr 25;117(2):214-21. doi: 10.1016/j.ijcard.2006.04.079. Epub 
      2006 Oct 24.