PMID- 17065132
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20181113
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 12
IP  - 5
DP  - 2006 Oct
TI  - Comparison of inflammatory infiltrates in trigeminal ganglia of cattle infected 
      with wild-type Bovine herpesvirus 1 versus a virus strain containing a mutation 
      in the LR (latency-related) gene.
PG  - 392-7
AB  - During latency, the bovine herpesvirus 1 (BHV-1) latency-related (LR) RNA is 
      abundantly expressed in neurons within trigeminal ganglia (TG). A LR mutant virus 
      that does not express two LR proteins is unable to reactivate from latency 
      following dexamethasone treatment. Increased infiltration of inflammatory cells 
      occurs in TG of calves acutely infected with the LR mutant virus. Throughout 
      acute infection, wild-type BHV-1 DNA is detected in neurons surrounded by 
      mononuclear infiltrates and in non-neuronal cells comprising the infiltrate. 
      Conversely, LR mutant DNA is only detected in neurons near the end of acute 
      infection, suggesting LR gene products promote virus spread in TG.
FAU - Perez, Sandra
AU  - Perez S
AD  - Department of Veterinary and Biomedical Sciences, Nebraska Center for Virology, 
      University of Nebraska, Lincoln, Nebraska 68583-0905, USA.
FAU - Lovato, Luciane
AU  - Lovato L
FAU - Zhou, Joe
AU  - Zhou J
FAU - Doster, Alan
AU  - Doster A
FAU - Jones, Clinton
AU  - Jones C
LA  - eng
GR  - 1P20RR15635/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cattle
MH  - Cattle Diseases/pathology/*virology
MH  - DNA, Viral/genetics
MH  - Herpesviridae Infections/pathology/*veterinary
MH  - *Herpesvirus 1, Bovine/genetics
MH  - Inflammation/psychology
MH  - Mutation
MH  - Polymerase Chain Reaction
MH  - Trigeminal Ganglion/*pathology/*virology
EDAT- 2006/10/27 09:00
MHDA- 2007/01/05 09:00
CRDT- 2006/10/27 09:00
PHST- 2006/10/27 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/10/27 09:00 [entrez]
AID - TW35V3324657R285 [pii]
AID - 10.1080/13550280600936459 [doi]
PST - ppublish
SO  - J Neurovirol. 2006 Oct;12(5):392-7. doi: 10.1080/13550280600936459.