PMID- 17065133
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20181113
IS  - 1355-0284 (Print)
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 12
IP  - 5
DP  - 2006 Oct
TI  - Recombinant antibodies generated from both clonal and less abundant plasma cell 
      immunoglobulin G sequences in subacute sclerosing panencephalitis brain are 
      directed against measles virus.
PG  - 398-402
AB  - Increased immunoglobulin G (IgG) and intrathecally produced oligoclonal bands 
      (OGBs) are characteristic of a limited number of inflammatory central nervous 
      system (CNS) diseases and are often directed against the cause of disease. In 
      subacute sclerosing panencephalitis (SSPE), the cause of disease and the target 
      of the oligoclonal response is measles virus (MV). The authors previously showed 
      that clonally expanded populations of CD38+ plasma cells in SSPE brain, the 
      likely source of OGBs, are directed against MV. In characterizing the breadth of 
      the plasma cell reactivities, the authors found that a large proportion of the 
      less abundant plasma cells are also directed against MV. The intrathecal response 
      may be useful in determining the causes of other inflammatory CNS diseases, such 
      as multiple sclerosis, Behcet's disease, and neurosarcoidosis.
FAU - Burgoon, Mark P
AU  - Burgoon MP
AD  - Department of Neurology, University of Colorado Health Sciences Center, Denver, 
      Colorado 80262, USA. mark.burgoon@uchsc.edu
FAU - Caldas, Yupanqui A
AU  - Caldas YA
FAU - Keays, Kathryne M
AU  - Keays KM
FAU - Yu, Xiaoli
AU  - Yu X
FAU - Gilden, Donald H
AU  - Gilden DH
FAU - Owens, Gregory P
AU  - Owens GP
LA  - eng
GR  - NS 41549/NS/NINDS NIH HHS/United States
GR  - R01 NS041549-05A2/NS/NINDS NIH HHS/United States
GR  - NS 32623/NS/NINDS NIH HHS/United States
GR  - P01 NS032623/NS/NINDS NIH HHS/United States
GR  - R01 NS041549/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Antigens, CD)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Recombinant Proteins)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
MH  - ADP-ribosyl Cyclase 1/blood/immunology
MH  - Amino Acid Sequence
MH  - Antigens, CD/blood/immunology
MH  - Humans
MH  - Immunoglobulin G/*blood/*genetics
MH  - Measles/*immunology
MH  - Molecular Sequence Data
MH  - Plasma Cells/immunology
MH  - Recombinant Proteins/blood/immunology
MH  - Subacute Sclerosing Panencephalitis/blood/*genetics/*immunology/pathology
PMC - PMC3277326
MID - NIHMS353891
EDAT- 2006/10/27 09:00
MHDA- 2007/01/05 09:00
PMCR- 2012/02/10
CRDT- 2006/10/27 09:00
PHST- 2006/10/27 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/10/27 09:00 [entrez]
PHST- 2012/02/10 00:00 [pmc-release]
AID - K111233758M3U6V7 [pii]
AID - 10.1080/13550280600957414 [doi]
PST - ppublish
SO  - J Neurovirol. 2006 Oct;12(5):398-402. doi: 10.1080/13550280600957414.