PMID- 17065583
OWN - NLM
STAT- MEDLINE
DCOM- 20070118
LR  - 20131121
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 60
IP  - 6
DP  - 2006 Dec
TI  - Total hydroperoxide and biological antioxidant potentials in a neonatal sepsis 
      model.
PG  - 675-9
AB  - Oxidant/antioxidant imbalance plays an important role in septic shock. The 
      present study examined changes in circulating oxidative components in a neonatal 
      sepsis model. Subjects were 14 newborn mixed-strain piglets randomly divided into 
      two groups: a cecal ligation and perforation (CLP) model (n = 7) and sham (n = 
      7). Blood samples for total hydroperoxide (TH), biological antioxidant potential 
      (BAP), tumor necrosis factor (TNF) alpha, interleukin (IL)-6, and IL-10 were 
      collected pre-CLP and at 1, 3, and 6 h post-CLP. TH and BAP levels at 1 h 
      post-CLP were significantly higher in the CLP group than in the sham group. In 
      the CLP group, TH decreased gradually and reached baseline levels by 6 h 
      post-CLP, while BAP remained elevated. Linear correlations were identified 
      between serum TH and BAP at 1 h post-CLP, serum TH and TNF-alpha at 1 h post-CLP, 
      and BAP and IL-6 at 6 h post-CLP. Changes in and correlations between circulating 
      oxidative and inflammatory state components in a neonatal sepsis model were 
      clarified. This is the first study to reveal that the presence of 
      oxidant/antioxidant imbalance in sepsis and septic shock changes during the 
      disease course.
FAU - Kakita, Hiroki
AU  - Kakita H
AD  - Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City 
      University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. 
      hkaki@med.nagoya-cu.ac.jp
FAU - Hussein, Mohamed H
AU  - Hussein MH
FAU - Daoud, Ghada A
AU  - Daoud GA
FAU - Kato, Takenori
AU  - Kato T
FAU - Murai, Hiroki
AU  - Murai H
FAU - Sugiura, Takahiro
AU  - Sugiura T
FAU - Mizuno, Keisuke
AU  - Mizuno K
FAU - Yamada, Yasumasa
AU  - Yamada Y
FAU - Ito, Tetsuya
AU  - Ito T
FAU - Fukuda, Sumio
AU  - Fukuda S
FAU - Kato, Ineko
AU  - Kato I
FAU - Suzuki, Satoshi
AU  - Suzuki S
FAU - Togari, Hajime
AU  - Togari H
LA  - eng
PT  - Journal Article
DEP - 20061025
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Antioxidants)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antioxidants/*metabolism
MH  - Blood Gas Analysis
MH  - Blood Pressure/physiology
MH  - Body Temperature/physiology
MH  - Disease Models, Animal
MH  - Gram-Negative Bacterial Infections/*metabolism/physiopathology
MH  - Gram-Positive Bacterial Infections/*metabolism/physiopathology
MH  - Hydrogen Peroxide/*blood
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Lipopolysaccharides/blood
MH  - Reactive Oxygen Species/metabolism
MH  - Sepsis/*metabolism/microbiology
MH  - Swine
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2006/10/27 09:00
MHDA- 2007/01/19 09:00
CRDT- 2006/10/27 09:00
PHST- 2006/10/27 09:00 [pubmed]
PHST- 2007/01/19 09:00 [medline]
PHST- 2006/10/27 09:00 [entrez]
AID - 01.pdr.0000245911.79943.8a [pii]
AID - 10.1203/01.pdr.0000245911.79943.8a [doi]
PST - ppublish
SO  - Pediatr Res. 2006 Dec;60(6):675-9. doi: 10.1203/01.pdr.0000245911.79943.8a. Epub 
      2006 Oct 25.