PMID- 17066205
OWN - NLM
STAT- MEDLINE
DCOM- 20070221
LR  - 20070621
IS  - 1684-1182 (Print)
IS  - 1684-1182 (Linking)
VI  - 39
IP  - 5
DP  - 2006 Oct
TI  - Risk factors and characteristics of early-onset asthma in Taiwanese children.
PG  - 414-21
AB  - BACKGROUND AND PURPOSE: Early-onset asthma has been reported to be associated 
      with a family history of allergy and exposure to environmental factors. This 
      study was designed to evaluate the relationship between age of onset of asthma 
      and genetic and environmental factors with asthma severity in Taiwanese children. 
      METHODS: A group of 352 children with asthma (220 males and 132 females), ranging 
      in age from 5 to 15 years, were enrolled in this study. The subjects were divided 
      into 2 groups: early-onset asthma (up to and including age 3) and late-onset 
      asthma. General characteristics including family history of allergies and 
      exposure to domestic pets and tobacco smoke were recorded. The subjects underwent 
      pulmonary function testing and analysis of serum immunoglobulin E (IgE), 
      eosinophil counts, and specific IgE for common allergens. RESULTS: Early-onset 
      asthma was present in 149 subjects and late-onset asthma in 203. Family history 
      of allergies included a sibling with asthma or urticaria predisposed to 
      early-onset asthma (asthma, p=0.034; urticaria, p=0.024). Food and milk allergen 
      sensitization were more common in early-onset asthma (food allergens, p=0.025; 
      milk, p=0.034). Children with early-onset asthma had higher eosinophil counts 
      (p=0.041). However, there was no correlation between age at onset and pulmonary 
      function testing, the levels of total IgE and IgE specific for Dermatophagoides 
      pteronyssinus or Dermatophagoides farinae. CONCLUSIONS: A history of asthma or 
      urticaria in a sibling is a risk factor for early-onset asthma. A greater 
      prevalence of food allergen sensitization and high eosinophil counts are 
      characteristic of early-onset disease.
FAU - Liang, Pei-Hsuan
AU  - Liang PH
AD  - Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Shyur, Shyh-Dar
AU  - Shyur SD
FAU - Huang, Li-Hsin
AU  - Huang LH
FAU - Wen, Da-Chin
AU  - Wen DC
FAU - Chiang, Yi-Chi
AU  - Chiang YC
FAU - Lin, Mao-Tsair
AU  - Lin MT
FAU - Yang, Hwai-Chih
AU  - Yang HC
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 0 (Allergens)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Allergens/adverse effects
MH  - Animals
MH  - Asthma/blood/*epidemiology/etiology
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Food Hypersensitivity
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Milk/adverse effects
MH  - Pyroglyphidae/immunology
MH  - Risk Factors
MH  - Siblings
MH  - Taiwan/epidemiology
MH  - Tobacco Smoke Pollution/adverse effects
MH  - Urticaria
EDAT- 2006/10/27 09:00
MHDA- 2007/02/22 09:00
CRDT- 2006/10/27 09:00
PHST- 2006/10/27 09:00 [pubmed]
PHST- 2007/02/22 09:00 [medline]
PHST- 2006/10/27 09:00 [entrez]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2006 Oct;39(5):414-21.