PMID- 17066297
OWN - NLM
STAT- MEDLINE
DCOM- 20070502
LR  - 20181113
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 120
IP  - 6
DP  - 2007 Feb
TI  - The possible role of 10398A and 16189C mtDNA variants in providing susceptibility 
      to T2DM in two North Indian populations: a replicative study.
PG  - 821-6
AB  - The role of mitochondria in causing diseases is becoming evident as more and more 
      studies are focusing on this organelle of the cell. This is largely attributed to 
      its reactive oxygen species (ROS) production property. In the context of 
      diabetes, ROS is suggested to trigger different forms of insulin resistance 
      involving different mechanisms. The suggestive role of a mtDNA variant G10398A in 
      increasing ROS production and the impaired response to oxidative stress due to 
      T16189C variant is worth addressing as genetic susceptibility factors in type 2 
      diabetes mellitus (T2DM). A case control study on 312 T2DM cases and ethnically 
      matched 466 controls involving two North Indian populations, referred as cohort 1 
      and cohort 2 (in a replicative study), was undertaken to test such a genetic 
      association. A statistically significant association was observed for 10398A 
      allele in both the cohorts [cohort1 (OR = 2.67 95% CI 1.77-4.00); cohort2 (OR = 
      1.76 95%CI 1.12-2.77)]. The analysis of G10398A/T16189C haplotypic combinations 
      revealed that 10398A/16189C haplotype provides a risk in both the cohorts. To sum 
      up the study suggests that 10398A and 16189C alleles provide susceptiblity to 
      T2DM independently as well as together.
FAU - Bhat, Audesh
AU  - Bhat A
AD  - National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal 
      Nehru University, New Delhi, India.
FAU - Koul, Anil
AU  - Koul A
FAU - Sharma, Swarkar
AU  - Sharma S
FAU - Rai, Ekta
AU  - Rai E
FAU - Bukhari, S I A
AU  - Bukhari SI
FAU - Dhar, M K
AU  - Dhar MK
FAU - Bamezai, R N K
AU  - Bamezai RN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061026
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - DNA, Mitochondrial/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Haplotypes
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
EDAT- 2006/10/27 09:00
MHDA- 2007/05/03 09:00
CRDT- 2006/10/27 09:00
PHST- 2006/06/24 00:00 [received]
PHST- 2006/10/02 00:00 [accepted]
PHST- 2006/10/27 09:00 [pubmed]
PHST- 2007/05/03 09:00 [medline]
PHST- 2006/10/27 09:00 [entrez]
AID - 10.1007/s00439-006-0272-4 [doi]
PST - ppublish
SO  - Hum Genet. 2007 Feb;120(6):821-6. doi: 10.1007/s00439-006-0272-4. Epub 2006 Oct 
      26.