PMID- 17067909
OWN - NLM
STAT- MEDLINE
DCOM- 20070320
LR  - 20061027
IS  - 1083-8791 (Print)
IS  - 1083-8791 (Linking)
VI  - 12
IP  - 10
DP  - 2006 Oct
TI  - The impact of human herpesvirus 6B reactivation on early complications following 
      allogeneic hematopoietic stem cell transplantation.
PG  - 1031-7
AB  - Although human herpesvirus 6 (HHV-6) has been considered an important 
      opportunistic and potentially fatal pathogen for allogeneic hematopoietic stem 
      cell transplantation (HSCT), the clinical significance of HHV-6 reactivation 
      remains controversial. In this study, we monitored HHV-6 DNAemia in 72 
      consecutive allogeneic HSCT recipients by real-time quantitative polymerase chain 
      reaction. A total of 680 peripheral blood specimens were collected from the 
      recipients before HSCT or at weekly intervals after HSCT. As the predominant 
      variant, HHV-6B was detectable at least once in 47.2% (34/72) of HSCT recipients 
      on the median day 21 (range, 7-84 days); HHV-6A reactivation occurred in only 1 
      recipient (1.4%). Detectable HHV-6B reactivation was associated with increased 
      probability of skin rash by day 30 after HSCT (hazard ratio [HR], 3.68; 95% 
      confidence interval [CI], 1.24-10.92; P = .019), cytomegalovirus (CMV) 
      antigenemia (HR, 2.35; 95%CI, 1.32-4.19; P = .004), and hemorrhagic cystitis (HC) 
      (HR, 2.59; 95%CI, 0.96-6.98; P = .061) by day 100 after HSCT. Neutrophil and 
      platelet engraftment, mortality for 100 days after HSCT were not affected by 
      HHV-6B reactivation. In conclusion, HHV-6 reactivation is a common event, and 
      this study demonstrates a correlation between HHV-6B infection and CMV 
      reactivation, early rash, and possibly increased incidence of HC after 
      transplantation.
FAU - Wang, Li-Ru
AU  - Wang LR
AD  - Peking University Institute of Hematology, Peking University People's Hospital, 
      Beijing, PR China.
FAU - Dong, Lu-Jia
AU  - Dong LJ
FAU - Zhang, Mei-Jie
AU  - Zhang MJ
FAU - Lu, Dao-Pei
AU  - Lu DP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Cystitis/*etiology/virology
MH  - Cytomegalovirus Infections/*complications
MH  - DNA, Viral/blood
MH  - Exanthema/etiology
MH  - Female
MH  - Graft Survival
MH  - Hematologic Neoplasms/complications/surgery
MH  - Hemorrhage/*etiology/virology
MH  - Herpesvirus 6, Human/isolation & purification/*physiology
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Peripheral Blood Stem Cell Transplantation
MH  - Postoperative Complications/*etiology/virology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Roseolovirus Infections/*complications/virology
MH  - Seizures/etiology
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - Viremia/*complications/virology
MH  - *Virus Activation
EDAT- 2006/10/28 09:00
MHDA- 2007/03/21 09:00
CRDT- 2006/10/28 09:00
PHST- 2006/02/14 00:00 [received]
PHST- 2006/06/02 00:00 [accepted]
PHST- 2006/10/28 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2006/10/28 09:00 [entrez]
AID - S1083-8791(06)00409-5 [pii]
AID - 10.1016/j.bbmt.2006.06.001 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2006 Oct;12(10):1031-7. doi: 
      10.1016/j.bbmt.2006.06.001.